Megestrol Acetate and Solesta

• Generic Name: megestrol
• Dosage Forms: n.a.
• Other Brand Names: Megace ES, Megace

Palliative management of recurrent, inoperable, or metastatic breast cancer.

Estrogen and/or progesterone receptor-positive breast cancer is more likely to respond to megestrol therapy.

Does not replace appropriate methods of treatment of advanced breast cancer (e.g., surgery, radiation, chemotherapy).

Not recommended for treatment of other types of neoplastic disease; use only for treatment of breast cancer or endometrial cancer.

Palliative management of recurrent, inoperable, or metastatic endometrial carcinoma.

Does not replace appropriate methods of treatment of advanced endometrial carcinoma (e.g., surgery, radiation, chemotherapy).

Not recommended for treatment of other types of neoplastic disease; use only for treatment of endometrial cancer or breast cancer.

Management of anorexia, cachexia, or an unexplained, substantial weight loss in HIV-infected individuals (designated an orphan drug by FDA for this use).

Also has been used to stimulate appetite and promote weight gain in a limited number of patients with cachexia associated with neoplastic disease.

Therapy should be initiated only after treatable causes (e.g., possible malignancies; systemic infections; GI disorders affecting absorption; endocrine, renal, or psychiatric diseases) of the condition have been evaluated.

Manufacturer states that megestrol should not be used prophylactically to avoid weight loss.

• Generic Name: dextranomer / sodium hyaluronate
• Dosage Forms: n.a.
• Other Brand Names: Solesta

Solesta are natural materials formed into a gel that is similar to certain substances that occur naturally in your body. Solesta works by thickening the tissues in your anal canal.

Solesta is injected as an implant into your anal canal to treat fecal incontinence (loss of bowel control) in adults.

This medicine is usually given after diet changes and other medications have been tried without success.

Solesta may also be used for purposes not listed in this medication guide.