Mellaril and Nitro-Bid Transdermal
Determining the interaction of Mellaril and Nitro-Bid Transdermal and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Thioridazine and nitroglycerin may have additive effects in lowering your blood pressure. You may experience headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate. These side effects are most likely to be seen at the beginning of treatment, following a dose increase, or when treatment is restarted after an interruption. Let your doctor know if you develop these symptoms and they do not go away after a few days or they become troublesome. Avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medications affect you, and use caution when getting up from a sitting or lying position. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Phenothiazines and neuroleptic agents may potentiate the hypotensive effect of some medications secondary to their peripheral alpha-1 adrenergic blocking activity. Orthostatic hypotension and syncope associated with vasodilation may occur, particularly during initial dosing and/or parenteral administration of the phenothiazine or neuroleptic.
MANAGEMENT: Close clinical monitoring for development of hypotension is recommended if phenothiazines or neuroleptic agents are used in patients receiving antihypertensive medications or vasodilators. A lower starting dosage and slower titration of the phenothiazine or neuroleptic may be appropriate, especially in the elderly. Patients should be advised to avoid rising abruptly from a sitting or recumbent position and to notify their physician if they experience dizziness, lightheadedness, syncope, orthostasis, or tachycardia. Patients should also avoid driving or operating hazardous machinery until they know how the medications affect them.
- "Product Information. Rexulti (brexpiprazole)." Otsuka American Pharmaceuticals Inc, Rockville, MD.
- "Product Information. Clozaril (clozapine)." Novartis Pharmaceuticals, East Hanover, NJ.
- "Product Information. Risperdal (risperidone)." Janssen Pharmaceutica, Titusville, NJ.
- Fruncillo R, Gibbons W, Vlasses P, Ferguson R "Severe hypotension associated with concurrent clonidine and antipsychotic medication." Am J Psychiatry 142 (1985): 274
- "Product Information. Geodon (ziprasidone)." Pfizer US Pharmaceuticals, New York, NY.
- Aronowitz JS, Chakos MH, Safferman AZ, Lieberman JA "Syncope associated with the combination of clozapine and enalapril." J Clin Psychopharmacol 14 (1994): 429-30
- White WB "Hypotension with postural syncope secondary to the combination of chlorpromazine and captopril." Arch Intern Med 146 (1986): 1833-4
- "Product Information. Zyprexa (olanzapine)." Lilly, Eli and Company, Indianapolis, IN.
- "Product Information. Seroquel (quetiapine)." Zeneca Pharmaceuticals, Wilmington, DE.
- "Product Information. Abilify (aripiprazole)." Bristol-Myers Squibb, Princeton, NJ.
- Markowitz JS, Wells BG, Carson WH "Interactions between antipsychotic and antihypertensive drugs." Ann Pharmacother 29 (1995): 603-9
Generic Name: thioridazine
Brand name: Mellaril, Mellaril-S
Synonyms: n.a.
Generic Name: nitroglycerin
Brand name: Nitro-Bid, Nitrol Appli-Kit, Gonitro, Nitrolingual, NitroMist, Nitrostat, Nitro-Time, Gonitro, Minitran, Nitro TD Patch-A, Nitro-Dur, Rectiv
Synonyms: Nitro-Bid (topical), Nitro-Bid
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Mellaril-Nitro-Dur
- Mellaril-Nitro-Dur 0.2
- Mellaril-Nitro-Dur 0.3
- Mellaril-Nitro-Dur 0.4
- Mellaril-Nitro-Dur 0.6
- Mellaril-Nitro-Dur 0.8
- Nitro-Bid Transdermal-Melodetta 24 Fe
- Nitro-Bid Transdermal-Meloxicam
- Nitro-Bid Transdermal-Meloxicam Capsules
- Nitro-Bid Transdermal-Meloxicam Oral Suspension
- Nitro-Bid Transdermal-Meloxicam Orally-Disintegrating Tablets
- Nitro-Bid Transdermal-Meloxicam Suspension