Melphalan and Thiotepa
Determining the interaction of Melphalan and Thiotepa and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Ask your doctor before using melphalan together with thiotepa. This combination can increase the blood levels or add to the medication side effects of melphalan. You may need a dose adjustment or special tests to safely take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Thiotepa may intensify the toxicity of other alkylating agents (or radiation) rather than enhance therapeutic response.
MANAGEMENT: It is not advisable to combine chemotherapeutic agents (or modalities) that have the same mechanism of action. If these agents must follow each other, it is important that recovery from the first agent (or modality) be complete, as indicated by white blood cell count, before therapy with a second agent (or modality) is instituted.
- "Product Information. Thiotepa (thiotepa)." Hikma USA (formerly West-Ward Pharmaceutical Corporation), Eatontown, NJ.
Generic Name: melphalan
Brand name: Alkeran, Alkeran IV, Evomela
Synonyms: Melphalan (oral/injection)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Melphalan-Thiotepa Injection
- Melphalan-Thiothixene
- Melphalan-Thonzylamine and Chlophedianol
- Melphalan-Thorazine
- Melphalan-Thorazine (Chlorpromazine Injection)
- Melphalan-Thorazine (Chlorpromazine Tablets)
- Thiotepa-Melphalan Injection
- Thiotepa-Melphalan Intravenous
- Thiotepa-Melphalan oral/injection
- Thiotepa-Melphalan Tablets
- Thiotepa-Memantine
- Thiotepa-Memantine and Donepezil