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Melphalan Intravenous and Rubex

Determining the interaction of Melphalan Intravenous and Rubex and the possibility of their joint administration.

Check result:

Melphalan Intravenous <> Rubex

Relevance: 09.11.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Limited anecdotal data suggest an increased risk of doxorubicin-induced cardiomyopathy in patients who have previously received melphalan. The mechanism of this suspected interaction is unknown. Although conclusive proof that melphalan sensitizes the myocardium is lacking, anthracyclines should be administered cautiously to patients who have had extensive melphalan therapy.

References

Bitran JD "Doxorubicin cardiotoxicity and melphalan" Ann Intern Med 95 (1981): 243-4

Melphalan Intravenous

Generic Name: melphalan

Brand name: Alkeran, Alkeran IV, Evomela

Synonyms: Melphalan (oral/injection), Melphalan

What is Melphalan Intravenous?

Rubex

Generic Name: doxorubicin

Brand name: Adriamycin, Adriamycin RDF, Rubex, Adriamycin PFS

Synonyms: Doxorubicin, DOXOrubicin (Conventional)

What is Rubex?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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