Memantine and Donepezil and Terbinafine Oral Granules
Determining the interaction of Memantine and Donepezil and Terbinafine Oral Granules and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Coadministration with inhibitors of CYP450 2D6 and/or 3A4 may increase the plasma concentrations of donepezil, which is primarily metabolized by these isoenzymes. In a 7-day crossover study in 18 healthy volunteers, the potent CYP450 3A4 inhibitor ketoconazole (200 mg once daily) increased the mean peak plasma concentration (Cmax) and systemic exposure (AUC) of donepezil (5 mg once daily) by approximately 36% each. The clinical relevance of these increases is unknown.
- "Product Information. Aricept (donepezil)." Pfizer US Pharmaceuticals, New York, NY.
- Rojas-Fernandez C, Fisher C "Drug interactions and donepezil." J Am Geriat Soc 40 (2000): 597-8
- Tiseo PJ, Perdomo CA, Friedhoff LT "Concurrent administration of donepezil HCl and ketoconazole: assessment of pharmacokinetic changes following single and multiple doses." Br J Clin Pharmacol 46 (1998): 30-4
Generic Name: donepezil / memantine
Brand name: Namzaric, Namzaric Titration Pack
Synonyms: Donepezil and memantine
Generic Name: terbinafine
Brand name: Lamisil, Terbinex
Synonyms: Terbinafine, Terbinafine (Systemic)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Memantine and Donepezil-Terbinafine Tablets
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- Memantine and Donepezil-Terbinex
- Memantine and Donepezil-Terbutaline
- Memantine and Donepezil-Terbutaline Injection
- Memantine and Donepezil-Terbutaline Subcutaneous
- Terbinafine Oral Granules-Memantine and Donepezil Capsules
- Terbinafine Oral Granules-Memantine ER capsules
- Terbinafine Oral Granules-Memantine ER Tablets
- Terbinafine Oral Granules-Memantine Extended-Release Capsules
- Terbinafine Oral Granules-Memantine Hydrochloride
- Terbinafine Oral Granules-Memantine Oral Solution