Memantine and Donepezil Capsules and Miconazole Buccal mucosa
Determining the interaction of Memantine and Donepezil Capsules and Miconazole Buccal mucosa and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Coadministration with inhibitors of CYP450 2D6 and/or 3A4 may increase the plasma concentrations of donepezil, which is primarily metabolized by these isoenzymes. In a 7-day crossover study in 18 healthy volunteers, the potent CYP450 3A4 inhibitor ketoconazole (200 mg once daily) increased the mean peak plasma concentration (Cmax) and systemic exposure (AUC) of donepezil (5 mg once daily) by approximately 36% each. The clinical relevance of these increases is unknown.
- "Product Information. Aricept (donepezil)." Pfizer US Pharmaceuticals, New York, NY.
- Rojas-Fernandez C, Fisher C "Drug interactions and donepezil." J Am Geriat Soc 40 (2000): 597-8
- Tiseo PJ, Perdomo CA, Friedhoff LT "Concurrent administration of donepezil HCl and ketoconazole: assessment of pharmacokinetic changes following single and multiple doses." Br J Clin Pharmacol 46 (1998): 30-4
Generic Name: donepezil / memantine
Brand name: Namzaric, Namzaric Titration Pack
Synonyms: Donepezil and memantine, Memantine and Donepezil
Generic Name: miconazole
Brand name: Oravig, Monistat IV, Oravig
Synonyms: Miconazole oral (buccal), Miconazole (Oral)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Memantine and Donepezil Capsules-Miconazole Cream and Ointment
- Memantine and Donepezil Capsules-Miconazole Liquid
- Memantine and Donepezil Capsules-Miconazole Nitrate
- Memantine and Donepezil Capsules-Miconazole oral buccal
- Memantine and Donepezil Capsules-Miconazole Powder
- Memantine and Donepezil Capsules-Miconazole Spray and Spray Powder
- Miconazole Buccal mucosa-Memantine ER capsules
- Miconazole Buccal mucosa-Memantine ER Tablets
- Miconazole Buccal mucosa-Memantine Extended-Release Capsules
- Miconazole Buccal mucosa-Memantine Hydrochloride
- Miconazole Buccal mucosa-Memantine Oral Solution
- Miconazole Buccal mucosa-Memantine Solution