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Memantine Hydrochloride and Stalevo 100

Determining the interaction of Memantine Hydrochloride and Stalevo 100 and the possibility of their joint administration.

Check result:

Memantine Hydrochloride <> Stalevo 100

Relevance: 08.12.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

When COMT inhibitors are administered together with levodopa/carbidopa, they may increase the relative bioavailability (AUC) of levodopa. This is due to a decrease in levodopa clearance resulting in a prolongation of the terminal elimination half-life of levodopa (from approximately 2 hours to 3.5 hours).

In the presence of the decarboxylase inhibitor carbidopa, catechol-O-methyltransferase (COMT) is the major metabolizing enzyme for levodopa. In clinical trials of COMT inhibitors (administered concomitantly with levodopa), patients required a decrease in their daily levodopa dose if their daily dose of levodopa was greater than 600 mg for tolcapone or 800 mg for entacapone or if the patients had moderate or severe dyskinesias before beginning treatment. Although COMT inhibitors are intended for use with along with levodopa/carbidopa, the clinician should be aware that the dose of levodopa may need to be decreased when they are added to the patients drug regimen. This is especially true if the patient is experiencing dyskinesias induced by levodopa. Use with caution with severe dyskinesias or dystonia.

References

Dingemanse J, Jorga K, Zurcher G, Schmitt M, Sedek G, Da Prada M, Van Brummelen P "Pharmacokinetic-pharmacodynamic interaction between the COMT inhibitor tolcapone and single-dose levodopa." Br J Clin Pharmacol 40 (1995): 253-62
"Product Information. Comtan (entacapone)" Novartis Pharmaceuticals, East Hanover, NJ.
Sedek G, Jorga K, Schmitt M, Burns RS, Leese P "Effect of tolcapone on plasma levodopa concentrations after coadministration with levodopa/carbidopa to healthy volunteers." Clin Neuropharmacol 20 (1997): 531-41
Baas H, Beiske AG, Ghika J, Jackson M, Oertel WH, Poewe W, Ransmayr G "Catechol-O-methyltransferase inhibition with tolcapone reduces the "wearing off" phenomenon and levodopa requirements in fluctuatin parkinsonian patients." J Neurol Neurosurg Psychiatry 63 (1997): 421-8
"Product Information. Tasmar (tolcapone)." Valeant Pharmaceuticals, Costa Mesa, CA.

Memantine Hydrochloride

Generic Name: memantine

Brand name: Namenda, Namenda XR

Synonyms: Memantine

What is Memantine Hydrochloride?

Stalevo 100

Generic Name: carbidopa / entacapone / levodopa

Brand name: Stalevo 100, Stalevo 125, Stalevo 150, Stalevo 200, Stalevo 50, Stalevo 75, Stalevo

Synonyms: n.a.

What is Stalevo 100?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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