Meperidine and Promethazine and Zovirax Injection
Determining the interaction of Meperidine and Promethazine and Zovirax Injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using meperidine together with acyclovir may increase the effects of meperidine. Contact your doctor if you experience extreme drowsiness, muscle weakness, confusion, cold and clammy skin, pinpoint pupils, shallow breathing, slow heart rate, fainting, or coma. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Acyclovir may increase the plasma concentrations of meperidine and normeperidine, the metabolite that has been associated with adverse effects such as lethargy, agitation, and seizures. The mechanism of interaction is unknown. Increased pharmacologic and adverse effects of meperidine may occur.
MANAGEMENT: Caution is recommended if meperidine is used with acyclovir or its prodrug, valacyclovir. Patients should be monitored for tremor, seizures, CNS and respiratory depression, and cardiac arrhythmias.
- Johnson R, Douglas J, Corey L, Krasney H "Adverse effects with acyclovir and meperidine." Ann Intern Med 103 (1985): 962-3
- "Product Information. Demerol (meperidine)." Sanofi Winthrop Pharmaceuticals, New York, NY.
Generic Name: meperidine / promethazine
Brand name:
Synonyms: n.a.
Generic Name: acyclovir
Brand name: Sitavig, Zovirax
Synonyms: Zovirax
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Meperidine and Promethazine-Zovirax Ointment
- Meperidine and Promethazine-Zovirax Oral, Intravenous
- Meperidine and Promethazine-Zovirax Suspension
- Meperidine and Promethazine-Zovirax Topical
- Meperidine and Promethazine-ZTlido
- Meperidine and Promethazine-Zubsolv
- Zovirax Injection-Meperidine and Promethazine Capsules
- Zovirax Injection-Meperidine Hydrochloride
- Zovirax Injection-Meperidine Injection
- Zovirax Injection-Meperidine Syrup and Oral Solution
- Zovirax Injection-Meperidine Tablets
- Zovirax Injection-Meperitab