Meperitab and Phenytoin injection

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Ask your doctor before using meperidine together with phenytoin. Using these medications together can increase the effects of meperidine, which can lead to symptoms such as drowsiness, agitation, and seizures. You may need a dose adjustment or special tests to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Phenytoin may induce the metabolism of meperidine to normeperidine, the latter of which has been associated with adverse effects such as lethargy, agitation, and seizures. The interaction may decrease the therapeutic effects of meperidine while increasing its adverse effects. In four healthy volunteers, phenytoin (300 mg daily for 10 days) increased the systemic clearance of meperidine by 26%, decreased its elimination half-life by 33%, and decreased its oral bioavailability by 30%. Systemic exposure (AUC) of normeperidine from intravenous and oral meperidine increased by 53% and 25%, respectively, during coadministration with phenytoin.

MANAGEMENT: Meperidine product labeling recommends that the combination of meperidine and phenytoin be avoided. The same precaution may be applicable to other hydantoins, although clinical data are lacking.

Meperitab

Generic Name: meperidine

Brand name: Demerol, Meperitab, Demerol HCl

Synonyms: n.a.

What is Meperitab?

Phenytoin injection

Generic Name: phenytoin

Brand name: Dilantin, Phenytek, Dilantin Infatabs, Phenytoin Sodium, Prompt

Synonyms: Phenytoin

What is Phenytoin injection?