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Mephyton and Prevalite

Determining the interaction of Mephyton and Prevalite and the possibility of their joint administration.

Check result:

Mephyton <> Prevalite

Relevance: 07.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Cholestyramine may interfere with the absorption of phytonadione. You should take phytonadione at least 1 hour before or 4 to 6 hours after cholestyramine. Talk to your doctor or pharmacist if you have questions on how to take these or other medications you are prescribed. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

ADJUST DOSING INTERVAL: Cholestyramine may impair the absorption of oral vitamin K.

MANAGEMENT: If oral vitamin K is given concurrently, it should be taken at least 1 hour before or 4 to 6 hours after cholestyramine.

References

Acuna R, Gonzalez Ceron M "Hypoprothrombinemia and bleeding associated to treatment with cholestyramine (author's transl)." Rev Med Chil 105 (1977): 27-8
Longstreth GF, Newcomer AD "Drug-induced malabsorption." Mayo Clin Proc 50 (1975): 284-93
Gross L, Brotman M "Hypoprothrombinemia and hemorrhage associated with cholestyramine therapy." Ann Intern Med 72 (1970): 95-6
Shojania AM, Grewar D "Hypoprothrombinemic hemorrhage due to cholestyramine therapy." Can Med Assoc J 134 (1986): 609-10

Mephyton

Generic Name: phytonadione

Brand name: Mephyton, Aquamephyton, Konakion, Vitamin K1

Synonyms: n.a.

What is Mephyton?

Prevalite

Generic Name: cholestyramine

Brand name: Cholestyramine Light, Prevalite, Questran, Questran Light, Locholest, Locholest Light, Questran Light Packets, Prevalite Packets, Questran Packets

Synonyms: n.a.

What is Prevalite?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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