Mercaptopurine Suspension and Methotrexate injection
Determining the interaction of Mercaptopurine Suspension and Methotrexate injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Methotrexate inhibits the hepatic metabolism of the thiopurines. Decreased first-pass metabolism and increased bioavailability result. The clinical significance of this interaction has not been determined and is probably insignificant with standard intermittent oral doses of methotrexate. Generally the combination has beneficial effects when used in the treatment of acute lymphoblastic leukemia.
- Balis FM, Holcenberg JS, Zimm S, et al "The effect of methotrexate on the bioavailability of oral 6-mercaptopurine." Clin Pharmacol Ther 41 (1987): 384-7
Generic Name: mercaptopurine
Brand name: Purixan, Purinethol
Synonyms: Mercaptopurine
Generic Name: methotrexate
Brand name: Otrexup, Rasuvo, Rheumatrex Dose Pack, Trexall, Xatmep, Methotrexate Sodium, Preservative Free
Synonyms: Methotrexate
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Mercaptopurine Suspension-Methotrexate Injection (Subcutaneous)
- Mercaptopurine Suspension-Methotrexate Oral Solution
- Mercaptopurine Suspension-Methotrexate Oral, Injection
- Mercaptopurine Suspension-Methotrexate Sodium
- Mercaptopurine Suspension-Methotrexate Tablets
- Mercaptopurine Suspension-Methoxsalen
- Methotrexate injection-Mercaptopurine Tablets
- Methotrexate injection-Meridia
- Methotrexate injection-Meropenem
- Methotrexate injection-Meropenem and vaborbactam
- Methotrexate injection-Meropenem and vaborbactam Intravenous
- Methotrexate injection-Meropenem Intravenous