Meropenem and Probenecid and colchicine
Determining the interaction of Meropenem and Probenecid and colchicine and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Ask your doctor before using probenecid together with meropenem. Using probenecid with meropenem can increase the effects of meropenem. Let your doctor know if you have a history of seizures, kidney or liver problems. You may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Coadministration with probenecid may increase the plasma concentrations of meropenem. The mechanism involves competitive inhibition of the renal excretion of meropenem via active tubular secretion. In pharmacokinetic studies, probenecid increased meropenem systemic exposure (AUC) by 56% and elimination half-life by 38%.
MANAGEMENT: The use of meropenem in combination with probenecid is not recommended by the manufacturer.
- "Product Information. Merrem (meropenem)." Zeneca Pharmaceuticals, Wilmington, DE.
- Bax RP, Bastain W, Featherstone A, Wilkinson DM, Hutchison M, Haworth SJ "The pharmacokinetics of meropenem in volunteers." J Antimicrob Chemother 24(suppl a (1989): 311-20
Generic Name: meropenem
Brand name: Merrem, Merrem Novaplus
Synonyms: n.a.
Generic Name: colchicine / probenecid
Brand name:
Synonyms: Probenecid and colchicine (Oral)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Meropenem-Probenecid Tablets
- Meropenem-Probiotic Formula (Bacillus Coagulans)
- Meropenem-Probucol
- Meropenem-Probuphine
- Meropenem-Procainamide
- Meropenem-Procainamide capsules
- Probenecid and colchicine-Meropenem and vaborbactam
- Probenecid and colchicine-Meropenem and vaborbactam Intravenous
- Probenecid and colchicine-Meropenem Intravenous
- Probenecid and colchicine-Merrem
- Probenecid and colchicine-Merrem IV
- Probenecid and colchicine-Merthiolate