Mesantoin and Omeprazole and sodium bicarbonate
Determining the interaction of Mesantoin and Omeprazole and sodium bicarbonate and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Before taking mephenytoin, tell your doctor if you also use omeprazole. You may need dose adjustments or special tests in order to safely take both medications together. This combination may increase your mephenytoin levels. You should notify your doctor if you have symptoms such as drowsiness, visual problems, changes in behavior, nausea, or poor muscle coordination. It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.
Professional:MONITOR: Omeprazole may increase phenytoin serum concentrations and the risk of toxicity. The proposed mechanism is decreased clearance due to omeprazole-mediated inhibition of CYP450 2C19. Omeprazole may interact in a similar manner with other hydantoins. The clinical significance is unknown; however, higher omeprazole doses (more than 40 mg/day) may be more likely to interact.
MANAGEMENT: Clinical and laboratory monitoring may be appropriate whenever omeprazole is added to or withdrawn from therapy with phenytoin. Dosage adjustments may be considered if an interaction is suspected. Patients should be advised to notify their doctor if they experience symptoms of phenytoin toxicity (e.g., drowsiness, visual disturbances, change in mental status, seizures, nausea, or ataxia).
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- Cerner Multum, Inc. "Australian Product Information." O 0
- Gugler R, Jensen JC "Omeprazole inhibits oxidative drug metabolism: studies with diazepam and phenytoin in vivo and 7-ethoxycoumarin in vitro." Gastroenterology 89 (1985): 1235-41
- "Product Information. Prilosec (omeprazole)." Merck & Co, Inc, West Point, PA.
- Andersson T "Omeprazole drug interaction studies." Clin Pharmacokinet 21 (1991): 195-212
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Generic Name: omeprazole / sodium bicarbonate
Brand name: Zegerid, Zegerid OTC
Synonyms: Omeprazole and Sodium Bicarbonate
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Mesantoin-Omeprazole and Sodium Bicarbonate Capsule
- Mesantoin-Omeprazole and Sodium Bicarbonate Capsules
- Mesantoin-Omeprazole and Sodium Bicarbonate Powder Packets
- Mesantoin-Omeprazole Delayed-Release Capsules
- Mesantoin-Omeprazole Delayed-Release Capsules and Tablets (OTC)
- Mesantoin-Omeprazole Orally-Disintegrating Tablets
- Omeprazole and sodium bicarbonate-Mesasal Rectal
- Omeprazole and sodium bicarbonate-Mesehist WC
- Omeprazole and sodium bicarbonate-Mesna
- Omeprazole and sodium bicarbonate-Mesna Injection
- Omeprazole and sodium bicarbonate-Mesna Intravenous
- Omeprazole and sodium bicarbonate-Mesna oral/injection