About us Contacts Drug interactions: 390 212
Drug search by name

Mesantoin and TargaDOX

Determining the interaction of Mesantoin and TargaDOX and the possibility of their joint administration.

Check result:
Mesantoin <> TargaDOX
Relevance: 24.07.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Before using doxycycline, tell your doctor if you also use mephenytoin. You may need a dose adjustment or special tests in order to safely take both medications together. This may decrease the effectiveness of doxycycline. If you take both medications together, tell your doctor if your infection worsens. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Phenytoin (and other hydantoins) may significantly decrease doxycycline half-life resulting in decreased antimicrobial effectiveness. The mechanism may be related to induction of doxycycline metabolism.

MANAGEMENT: Patients should be monitored for altered doxycycline efficacy. It may be necessary to increase doxycycline dosage. Alternative antimicrobial therapy with a different tetracycline or a different class of antimicrobial agent may be preferable.

References
  • Neuvonen PJ, Penttila O, Lehtovaara R, Aho K "Effect of antiepileptic drugs on the elimination of various tetracycline derivatives." Eur J Clin Pharmacol 9 (1975): 147-54
  • Penttila O, Neuvonen PJ, Aho K, Lehtovaara R "Interaction between doxycycline and some antiepileptic drugs." Br Med J 2 (1974): 470-2
Mesantoin

Generic Name: mephenytoin

Brand name:

Synonyms: n.a.

TargaDOX

Generic Name: doxycycline

Brand name: Acticlate, Adox Pak 2/100, Adoxa, Adoxa Pak 1/100, Adoxa Pak 1/150, Avidoxy, Monodox, Morgidox, Oraxyl, TargaDOX, Vibramycin, Adoxa CK, Adoxa Pak, Adoxa TT, Alodox, Avidoxy, Doryx, Mondoxyne NL, Oracea, Periostat Targadox, Vibramycin Calcium, Vibramycin Hyclate, Vibramycin monohydrate, Vibra-Tabs, Doxy 100, TargaDOX

Synonyms: Targadox

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

Interaction with food and lifestyle
Disease interaction