Metafolbic and Rheumatrex
Determining the interaction of Metafolbic and Rheumatrex and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this interaction is not currently available.MONITOR: Coadministration of methotrexate with vitamin preparations containing folic acid, folinic acid (leucovorin) or their derivatives may diminish the therapeutic effects of methotrexate. The proposed mechanism involves pharmacodynamic antagonism and/or competitive inhibition at the receptor site. MANAGEMENT: Although folic acid or folinic acid are frequently used along with methotrexate to reduce adverse effects or as an antidote to high dose methotrexate therapy, patients receiving methotrexate should be advised to avoid the inadvertent use of vitamin preparations containing folic acid or its derivatives. References "Product Information. Methotrexate Sodium (methotrexate)." Teva Pharmaceuticals (formerly IVAX), Miami, FL. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0 Cerner Multum, Inc. "Australian Product Information." O 0
Professional:MONITOR: Coadministration of methotrexate with vitamin preparations containing folic acid, folinic acid (leucovorin) or their derivatives may diminish the therapeutic effects of methotrexate. The proposed mechanism involves pharmacodynamic antagonism and/or competitive inhibition at the receptor site.
MANAGEMENT: Although folic acid or folinic acid are frequently used along with methotrexate to reduce adverse effects or as an antidote to high dose methotrexate therapy, patients receiving methotrexate should be advised to avoid the inadvertent use of vitamin preparations containing folic acid or its derivatives.
- "Product Information. Methotrexate Sodium (methotrexate)." Teva Pharmaceuticals (formerly IVAX), Miami, FL.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- Cerner Multum, Inc. "Australian Product Information." O 0
Generic Name: l-methylfolate
Brand name: Deplin, L-Methylfolate Formula, XaQuil XR, L-Methylfolate Formula 75
Synonyms: L-methylfolate, Methylfolate
Generic Name: methotrexate
Brand name: Rheumatrex Dose Pack, Trexall, Xatmep, Otrexup, Rasuvo, Methotrexate Sodium, Preservative Free
Synonyms: Rheumatrex Dose Pack
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Metafolbic-Rheumatrex Dose Pack
- Metafolbic-Rheumatrex Dose Pack Oral
- Metafolbic-Rhinall
- Metafolbic-Rhinocort
- Metafolbic-Rhinocort Allergy
- Metafolbic-Rhinocort Aqua
- Rheumatrex-Metafolbic Plus
- Rheumatrex-Metafolbic Plus RF
- Rheumatrex-Metaglip
- Rheumatrex-Metamucil
- Rheumatrex-Metamucil (Psyllium Capsules)
- Rheumatrex-Metamucil (Psyllium Powder)