Metaglip and Verapamil Hydrochloride PM

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Verapamil may decrease the effects of metFORMIN. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Verapamil may decrease the glucose-lowering effects of metformin. The mechanism may involve verapamil inhibition of the organic cation transporter 1 (OCT1), thereby inhibiting hepatic uptake of metformin. In 12 healthy male subjects, sustained-release verapamil (180 mg a day for 3 days) significantly decreased the glucose-lowering effects of immediate-release metformin (1000 mg in the evening, 750 mg the following morning), as evidenced by a reduction in maximum blood glucose concentrations and the area under the glucose concentration-time curve by 62.5% and 238%, respectively.

MANAGEMENT: Caution is advised if verapamil and metformin are used concomitantly. Close clinical monitoring of glycemic control is recommended following initiation or discontinuation of these drugs, and the dosages may be adjusted as necessary.

Metaglip

Generic Name: glipizide / metformin

Brand name: Metaglip

Synonyms: n.a.

What is Metaglip?

Verapamil Hydrochloride PM

Generic Name: verapamil

Brand name: Calan, Isoptin SR, Verelan, Isoptin, Calan SR, Isoptin IV, Covera-HS, Verelan PM

Synonyms: Verapamil

What is Verapamil Hydrochloride PM?