Metaglip and Warfarin

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Before taking warfarin, tell your doctor if you also use glipiZIDE. You may need dose adjustments or special tests in order to safely take both medications together. You should check your blood sugar regularly. Symptoms of low blood sugar may include headache, dizziness, drowsiness, nervousness, confusion, tremor, hunger, weakness, or sweating. You should promptly report any signs of bleeding such as swelling, headache, dizziness, weakness, nosebleeds, bleeding of gums from brushing, prolonged bleeding from cuts, red or brown urine, or red or black stools. It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.

MONITOR: Oral sulfonylureas may enhance or reduce the hypoprothrombinemic response to oral anticoagulants. The mechanism may be related to displacement from plasma protein binding sites. In addition, coumarin anticoagulants may cause an increase in blood levels of hypoglycemic agents, possibly by inhibiting their hepatic metabolism. Clinical data have been highly variable.

MANAGEMENT: The patient should be monitored for altered anticoagulation (PT/INR) and altered glycemic effect when either of these drugs is added to or removed from a patient's regimen. Patients should be advised to regularly monitor their blood sugar, counseled on how to recognize and treat hypoglycemia (e.g., headache, dizziness, drowsiness, nausea, tremor, hunger, weakness, or palpitations), and to promptly report any signs of bleeding (pain, swelling, headache, dizziness, weakness, prolonged bleeding from cuts, vaginal bleeding, nosebleeds, bleeding of gums from brushing, red or brown urine, or red or black stools) to their physician.

Metaglip

Generic Name: glipizide / metformin

Brand name: Metaglip

Synonyms: n.a.

What is Metaglip?

Warfarin

Generic Name: warfarin

Brand name: Coumadin, Jantoven

Synonyms: n.a.

What is Warfarin?