Metformin and Midodrine
Determining the interaction of Metformin and Midodrine and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Theoretically, the coadministration with midodrine may result in decreased clearance of drugs that are primarily eliminated by active tubular secretion such as metformin, cimetidine, ranitidine, procainamide, flecainide, quinidine, and triamterene. The proposed mechanism is competitive inhibition of renal excretion by desglymidodrine, the active metabolite of midodrine. However, clinical data are lacking and no supportive experimental evidence exists. Patients receiving midodrine in combination with drugs that undergo active tubular secretion should be monitored for excessive effects of one or both drugs.
- "Product Information. ProAmatine (midodrine)." Roberts Pharmaceutical Corporation, Eatontown, NJ.
Generic Name: metformin
Brand name: Fortamet, Glucophage, Glucophage XR, Glumetza. Riomet, Glumetza, Riomet
Synonyms: MetFORMIN
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Metformin-Midodrine Hydrochloride
- Metformin-Midol
- Metformin-Midol Caffeine Free
- Metformin-Midol Complete
- Metformin-Midol Extended Relief
- Metformin-Midol IB
- Midodrine-Metformin and pioglitazone
- Midodrine-Metformin and repaglinide
- Midodrine-Metformin and saxagliptin
- Midodrine-Metformin and sitagliptin
- Midodrine-Metformin Extended-Release Tablets
- Midodrine-Metformin Hydrochloride