Metformin and repaglinide and Seconal Sodium

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Secobarbital may reduce the blood levels and effects of repaglinide. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring of your blood sugar to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of repaglinide, which is metabolized by the isoenzyme in the intestine and liver. In nine healthy volunteers, pretreatment with the CYP450 3A4 inducer rifampin (600 mg orally once a day for 5 days) decreased the mean peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) of repaglinide (0.5 mg single oral dose) by 41% and 57%, respectively, compared to placebo. The mean half-life was decreased by 27%, from 1.5 to 1.1 hours, by rifampin. Decreases in repaglinide Cmax (range 15% to 73%), AUC (range 30% to 78%), and half-life (range 1% to 37%) values were observed in every subject. There was also a significant difference in the glucose response to repaglinide between the rifampin and placebo phases. Specifically, rifampin reduced the mean decremental AUC from 0 to 3 hours of blood glucose by 76% and the maximum decrease in blood glucose concentration by 35% compared to placebo.

MANAGEMENT: Because the antidiabetic effect of repaglinide is dose- and concentration-dependent, patients treated concomitantly with rifampin may require a higher dosage of repaglinide. Blood glucose should be monitored more closely whenever a CYP450 3A4 inducer is added to or withdrawn from therapy in patients stabilized on their existing antidiabetic regimen, and the repaglinide dosage adjusted as necessary. Patients should be advised to contact their physician if they experience loss of glycemic control.

Metformin and repaglinide

Generic Name: metformin / repaglinide

Brand name: PrandiMet

Synonyms: Repaglinide and Metformin

What is Metformin and repaglinide?

Seconal Sodium

Generic Name: secobarbital

Brand name: Seconal Sodium, Seconal

Synonyms: n.a.

What is Seconal Sodium?