Metformin and saxagliptin and Vancocin HCl Pulvules
Determining the interaction of Metformin and saxagliptin and Vancocin HCl Pulvules and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using metFORMIN together with vancomycin may increase the effects of metFORMIN. You should monitor your blood glucose and contact your doctor if you experience weakness, increasing sleepiness, slow heart rate, cold feeling, muscle pain, shortness of breath, stomach pain, feeling light-headed, and fainting. You may need a dose adjustment and you may need to check your blood sugar more often to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Vancomycin is a cationic drug and theoretically could decrease the excretion of metformin by competing for renal tubular transport. Although this interaction has not been specifically reported for vancomycin, cimetidine (also a cationic drug) has been reported to interact with metformin in this manner. Increased metformin levels may increase the risk of lactic acidosis.
MANAGEMENT: If vancomycin and metformin must be used together, particularly slow and cautious titration of metformin dosage is recommended. The maximal dose of metformin probably also should be reduced until further information about this interaction is available. Patients should be advised to monitor their blood glucose and to promptly notify their physician if they experience possible signs of lactic acidosis such as malaise, myalgia, respiratory distress, hyperventilation, slow or irregular heartbeat, somnolence, abdominal upset, or other unusual symptoms.
- "Product Information. Glucophage (metformin)." Bristol-Myers Squibb, Princeton, NJ.
- Somogyi A, Stockley C, Keal J, Rolan P, Bochner F "Reduction of metformin renal tubular secretion by cimetidine in man." Br J Clin Pharmacol 23 (1987): 545-51
Generic Name: metformin / saxagliptin
Brand name: Kombiglyze XR
Synonyms: Saxagliptin and Metformin
Generic Name: vancomycin
Brand name: First-Vancomycin 25, First-Vancomycin 50, Vancocin HCl Pulvules, FIRST-Vancomycin, First-Vancomycin 25, First-Vancomycin 50, Firvanq, Vancocin
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Metformin and saxagliptin-Vancoled
- Metformin and saxagliptin-Vancomycin
- Metformin and saxagliptin-Vancomycin Capsules
- Metformin and saxagliptin-Vancomycin Hydrochloride
- Metformin and saxagliptin-Vancomycin injection
- Metformin and saxagliptin-Vancomycin Intravenous, Injection
- Vancocin HCl Pulvules-Metformin and sitagliptin
- Vancocin HCl Pulvules-Metformin Extended-Release Tablets
- Vancocin HCl Pulvules-Metformin Hydrochloride
- Vancocin HCl Pulvules-Metformin Oral Solution
- Vancocin HCl Pulvules-Metformin Tablets
- Vancocin HCl Pulvules-Methacholine