Methadone Injection Solution and Norvir
Determining the interaction of Methadone Injection Solution and Norvir and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using ritonavir together with methadone may decrease the effects of methadone. Contact your doctor if you experience withdrawal symptoms such as restlessness, insomnia, sweating, increased tears, and a runny nose. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Some protease inhibitors have been shown to decrease the plasma concentrations of methadone. In a study of healthy volunteers, peak serum concentration (Cmax) and area under the concentration-time curve (AUC) of methadone decreased by approximately 37% each during coadministration with ritonavir. Similar results have been reported with nelfinavir.
MANAGEMENT: Caution is advised if protease inhibitors are prescribed to patients treated with methadone. Pharmacologic response to methadone should be closely monitored and the dosage adjusted accordingly, particularly following initiation or discontinuation of protease inhibitor therapy in patients who are stabilized on their methadone regimen. Patients should be advised to notify their caregiver if they experience possible symptoms of methadone withdrawal such as restlessness, insomnia, sweating, lacrimation, and rhinorrhea.
- Geletko SM, Erickson AD "Decreased methadone effect after ritonavir initiation." Pharmacotherapy 20 (2000): 93-4
- Beauverie P, Taburet AM, Dessalles MC, Furlan V, Touzeau D "Therapeutic drug monitoring of methadone in HIV-infected patients receiving protease inhibitors." AIDS 12 (1998): 2510-1
Generic Name: methadone
Brand name: Dolophine, Methadose, Methadose Sugar-Free, Diskets
Synonyms: Methadone
Generic Name: ritonavir
Brand name: Norvir, Norvir Soft Gelatin
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Methadone Injection Solution-Norvir (Ritonavir Capsules)
- Methadone Injection Solution-Norvir (Ritonavir Oral Solution)
- Methadone Injection Solution-Norvir (Ritonavir Powder Packets)
- Methadone Injection Solution-Norvir (Ritonavir Tablets)
- Methadone Injection Solution-Norvir Tablets
- Methadone Injection Solution-Norwich Aspirin
- Norvir-Methadone Oral Concentrate
- Norvir-Methadone Oral Solution
- Norvir-Methadone Powder
- Norvir-Methadone Solution
- Norvir-Methadone Tablets
- Norvir-Methadone Tablets for Oral Suspension