Methadone Injection Solution and Rifabutin
Determining the interaction of Methadone Injection Solution and Rifabutin and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Theoretically, the coadministration of rifabutin and methadone may result in decreased plasma concentrations of the latter. The mechanism is accelerated clearance of methadone due to induction of hepatic CYP450 enzymatic activities by rifabutin. Although the interaction is fairly well-established for rifampin, a related agent, conflicting data exist for rifabutin. A study involving 24 patients failed to demonstrate a pharmacokinetic or pharmacodynamic effect of rifabutin on methadone, yet there have been isolated reports of patients who required increased methadone dosages during rifabutin administration due to withdrawal symptoms. These findings may be consistent with the fact that rifabutin is a much less potent CYP450 inducer than rifampin. In general, there does not appear to be a clinically significant interaction between rifabutin and methadone. As a precaution, however, it may be appropriate to monitor the pharmacologic response to methadone and adjust the dosage as necessary, particularly following initiation, discontinuation or change of dosage of rifabutin in patients who are stabilized on their methadone regimen. Patients should be advised to notify their caregiver if they experience possible symptoms of methadone withdrawal, including restlessness, insomnia, sweating, lacrimation, or rhinorrhea.
- Sawyer RC, Brown LS, Narang PK, Li R "Evaluation of a possible pharmacologic interaction between rifabutin (RIF) and methadone (MET) in HIV (+) injecting drug users (IDUs)." Int Conf AIDS 9 (1993): 501
- Brown LS, Sawyer RC, Li R, Cobb MN, Colborn DC, Narang PK "Lack of a pharmacologic interaction between rifabutin and methadone in HIV-infected former injecting drug users." Drug Alcohol Depend 43 (1996): 71-7
Generic Name: methadone
Brand name: Dolophine, Methadose, Methadose Sugar-Free, Diskets
Synonyms: Methadone
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Methadone Injection Solution-Rifadin
- Methadone Injection Solution-Rifadin IV
- Methadone Injection Solution-Rifadin IV Intravenous
- Methadone Injection Solution-Rifamate
- Methadone Injection Solution-Rifampin
- Methadone Injection Solution-Rifampin and Isoniazid
- Rifabutin-Methadone Oral Concentrate
- Rifabutin-Methadone Oral Solution
- Rifabutin-Methadone Powder
- Rifabutin-Methadone Solution
- Rifabutin-Methadone Tablets
- Rifabutin-Methadone Tablets for Oral Suspension