Methadone Injection Solution and Telaprevir

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Telaprevir may decrease the blood levels and effects of methadone. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes during treatment with these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with telaprevir may decrease the plasma concentrations of methadone. The mechanism of interaction has not been described. In 15 study subjects, administration of methadone maintenance therapy (40 to 120 mg/day) in combination with telaprevir (750 mg every 8 hours for 7 days) decreased overall methadone plasma concentrations by approximately one-third compared to administration alone. For the pharmacologically active R(+) enantiomer of methadone, peak plasma concentration (Cmax) and systemic exposure (AUC) decreased by an average of 29%, while trough plasma concentration (Cmin) decreased by an average of 31%. For the S(-) enantiomer, the Cmax and AUC decreased by an average of approximately 35% and Cmin decreased by an average of 40%.

MANAGEMENT: Caution is advised if telaprevir is prescribed to patients treated with methadone. Pharmacologic response to methadone should be closely monitored and the dosage adjusted accordingly, particularly following initiation or discontinuation of telaprevir in patients who are stabilized on their methadone regimen. Patients should be advised to notify their caregiver if they experience possible symptoms of methadone withdrawal such as restlessness, insomnia, sweating, lacrimation, and rhinorrhea.

Methadone Injection Solution

Generic Name: methadone

Brand name: Dolophine, Methadose, Methadose Sugar-Free, Diskets

Synonyms: Methadone

What is Methadone Injection Solution?

Telaprevir

Generic Name: telaprevir

Brand name: Incivek

Synonyms: Telaprevir (Oral)

What is Telaprevir?