Methadose and Pegasys ProClick
Determining the interaction of Methadose and Pegasys ProClick and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Coadministration with peginterferon alfa-2a may increase the plasma concentrations of methadone. The mechanism of interaction is unknown. In a pharmacokinetic study of 24 chronic hepatitis C patients receiving stable methadone maintenance therapy (median dose 95 mg, range 30 mg to 150 mg), treatment with peginterferon alfa-2a (180 mcg/kg subcutaneously once weekly) for 4 weeks was associated with methadone levels that were 10% to 15% higher than at baseline. The clinical significance of this finding is unknown. It may be appropriate to monitor for signs and symptoms of increased narcotic effect during coadministration of peginterferon alfa-2a and methadone. Methadone did not significantly affect the pharmacokinetics of peginterferon alfa-2a as compared to a pharmacokinetic study of 6 chronic hepatitis C patients not receiving methadone.
- "Product Information. Pegasys (peginterferon alfa-2a)." Roche Laboratories, Nutley, NJ.
Generic Name: methadone
Brand name: Methadose, Dolophine, Methadose Sugar-Free, Diskets
Synonyms: Methadose (Oral Concentrate)
Generic Name: peginterferon alfa-2a
Brand name: Pegasys, Pegasys ProClick Autoinjector, Pegasys Prefilled Syringe
Synonyms: Peginterferon alfa-2a, Peginterferon Alfa-2a
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Methadose-Pegfilgrastim
- Methadose-Pegfilgrastim On-body Injector
- Methadose-Pegfilgrastim Prefilled Syringes
- Methadose-Pegfilgrastim Subcutaneous
- Methadose-Pegfilgrastim-cbqv
- Methadose-Pegfilgrastim-jmdb
- Pegasys ProClick-Methadose (Methadone Oral Concentrate)
- Pegasys ProClick-Methadose (Methadone Tablets for Oral Suspension)
- Pegasys ProClick-Methadose (Methadone Tablets)
- Pegasys ProClick-Methadose Conc
- Pegasys ProClick-Methadose Disp
- Pegasys ProClick-Methamphetamine