Methadose (Methadone Oral Concentrate) and Olaparib
Determining the interaction of Methadose (Methadone Oral Concentrate) and Olaparib and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Olaparib may decrease the blood levels and effects of methadone. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with olaparib may decrease the plasma concentrations and therapeutic effects of drugs that are substrates of CYP450 1A2 and/or 2B6. The proposed mechanism, based on in vitro data, is increased clearance due to olaparib-mediated induction of CYP450 1A2 and/or 2B6.
MANAGEMENT: Caution is advised if olaparib is used concomitantly with drugs that are substrates of CYP450 1A2 and/or 2B6. Pharmacologic response and serum levels should be monitored more closely whenever olaparib is added to or withdrawn from therapy with these drugs. Dosage adjustments may be required if an interaction is suspected.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- Cerner Multum, Inc. "Australian Product Information." O 0
- EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring. Available from: URL: http://www.ema.europa.eu/ema/index.jsp?curl=pages/regulation/document_listing/document_listing_000366.jsp&mid=WC0b01ac058067c852" ([2013 - ]):
Generic Name: methadone
Brand name: Methadose, Dolophine, Methadose Sugar-Free, Diskets
Synonyms: Methadose (Oral Concentrate), Methadose
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Methadose (Methadone Oral Concentrate)-Olaparib Capsules
- Methadose (Methadone Oral Concentrate)-Olaparib Tablets
- Methadose (Methadone Oral Concentrate)-Olaratumab
- Methadose (Methadone Oral Concentrate)-Olaratumab Intravenous
- Methadose (Methadone Oral Concentrate)-Oleptro
- Methadose (Methadone Oral Concentrate)-Oleptro Oral
- Olaparib-Methadose (Methadone Tablets for Oral Suspension)
- Olaparib-Methadose (Methadone Tablets)
- Olaparib-Methadose Conc
- Olaparib-Methadose Disp
- Olaparib-Methamphetamine
- Olaparib-Methamphetamine Hydrochloride