Methadose (Methadone Tablets for Oral Suspension) and Pentothal
Determining the interaction of Methadose (Methadone Tablets for Oral Suspension) and Pentothal and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Narcotic analgesics may reduce the dosage of thiopental needed to induce anesthesia. Close monitoring of vital signs is necessary so that anesthetic dosages may be adjusted accordingly. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:ADJUST DOSE: Narcotic analgesics may reduce the dosage of barbiturate anesthetics needed to induce anesthesia by as much as 40%. Additionally, apnea is more common with this combination.
MANAGEMENT: Respiratory and cardiovascular status should be closely monitored, and anesthetic dosages titrated accordingly.
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- Stambaugh JE, Hemphill DM, Wainer IW, Schwartz I "A potentially toxic drug interaction between pethidine (meperidine) and phenobarbitone." Lancet 1 (1977): 398-9
- Dundee JW, Halliday NJ, McMurray TJ, Harper KW "Pretreatment with opioids: the effect on thiopentone induction requirements and on the onset of action of midazolam." Anaesthesia 41 (1986): 159-61
Generic Name: methadone
Brand name: Methadose, Dolophine, Methadose Sugar-Free, Diskets
Synonyms: Methadose (Oral Concentrate), Methadose
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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- Pentothal-Methadose (Methadone Tablets)
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