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Methenamine and Sulfatrim

Determining the interaction of Methenamine and Sulfatrim and the possibility of their joint administration.

Check result:

Methenamine <> Sulfatrim

Relevance: 15.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using methenamine together with sulfamethoxazole is not recommended. Combining these medications may cause crystals to form in the urine. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

CONTRAINDICATED: Some sulfonamides can form an insoluble precipitate with formaldehyde, which is generated from the hydrolysis of methenamine in acidic urine maintained by the presence of hippuric acid.

MANAGEMENT: Methenamine preparations should not be given to patients taking sulfonamides due to the risk of crystalluria. An alkalinizing agent should not be added because this may render methenamine less effective.

References

"Product Information. Urised (methenamine)." Polymedica Pharmaceuticals USA Inc, Woburn, MA.
"Product Information. Hiprex (methenamine)." Hoechst Marion-Roussel Inc, Kansas City, MO.

Methenamine

Generic Name: methenamine

Brand name: Hiprex, Mandelamine, Urex

Synonyms: n.a.

What is Methenamine?

Sulfatrim

Generic Name: sulfamethoxazole / trimethoprim

Brand name: Bactrim, Bactrim DS, Bactrim IV, Septra IV, SMZ-TMP DS, Sulfatrim Pediatric, Septra, Sulfatrim, Bethaprim, Cotrim, Uroplus, Uroplus DS, Cotrim DS, Bactrim Pediatric, Bethaprim Pediatric, Sulfatrim Suspension, Cotrim Pediatric, Septra DS

Synonyms: Sulfatrim (Oral)

What is Sulfatrim?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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