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Methergine and Oralair

Determining the interaction of Methergine and Oralair and the possibility of their joint administration.

Check result:
Methergine <> Oralair
Relevance: 04.12.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using mixed grass pollens allergen extract together with methylergonovine may not be advisable. Immunotherapy with mixed grass pollens allergen extract can sometimes cause severe, even potentially life-threatening allergic reactions that require emergency treatment with epinephrine, and medications like methylergonovine can interfere with the body's response to epinephrine and significantly reduce its effectiveness. Talk to your doctor if you have any questions or concerns. Stop using mixed grass pollens allergen extract, administer epinephrine, and seek immediate medical attention if signs and symptoms of an allergic reaction develop such as trouble breathing, swallowing, or speaking; throat tightness or swelling; dizziness, lightheadedness, or fainting; rapid or weak heartbeat; severe stomach cramps or pain; vomiting or diarrhea; and/or severe flushing or itching. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Alpha-adrenergic blockers and ergot alkaloids may attenuate the response to epinephrine in the treatment of serious systemic reactions, including anaphylaxis, that may occur during immunotherapy with allergenic extracts. Specifically, alpha-adrenergic blockers may antagonize the vasoconstricting and hypertensive effects of epinephrine, while ergot alkaloids can reverse the pressor effects of epinephrine.

MANAGEMENT: Immunotherapy with allergenic extracts may not be appropriate in patients receiving alpha-adrenergic blockers or ergot alkaloids, as these patients may be unresponsive to the usual doses of epinephrine required to reverse a systemic reaction.

References
  • "Product Information. Oralair (mixed grass pollens allergen extract)." Greer Laboratories Inc, Lenoir, NC.
  • "Product Information. Grastek (timothy grass pollen allergen extract)." Merck & Company Inc, Whitehouse Station, NJ.
  • "Product Information. Ragwitek (ragweed pollen allergen extract)." Merck & Company Inc, Whitehouse Station, NJ.
Methergine

Generic Name: methylergonovine

Brand name: Methergine

Synonyms: Methergine (oral and injection)

Oralair

Generic Name: mixed grass pollens allergen extract

Brand name: Oralair

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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