Methotrexate injection and Sodium Citrate and Citric Acid Oral Solution
Determining the interaction of Methotrexate injection and Sodium Citrate and Citric Acid Oral Solution and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Alkalinization of the urine can increase the renal elimination of methotrexate. The pharmacologic effects of methotrexate may be decreased. No special clinical interventions appear to be necessary. In some cases of methotrexate toxicity, this interaction may prove beneficial.
- Nirenberg A, Mosende C, Mehta BM, Gisolfi AL, Rosen G "High-dose methotrexate with citrovorum factor rescue: predictive value of serum methotrexate concentrations and corrective measures to avert toxicity." Cancer Treat Rep 61 (1977): 779-83
- Stoller RG, Hande KR, Jacobs SA, Rosenberg SA, Chabner BA "Use of plasma pharmacokinetics to predict and prevent methotrexate toxicity." N Engl J Med 297 (1977): 630-4
- Sand TE, Jacobsen S "Effect of urine pH and flow on renal clearance of methotrexate." Eur J Clin Pharmacol 19 (1981): 453-6
Generic Name: methotrexate
Brand name: Otrexup, Rasuvo, Rheumatrex Dose Pack, Trexall, Xatmep, Methotrexate Sodium, Preservative Free
Synonyms: Methotrexate
Generic Name: citric acid / sodium citrate
Brand name: Bicitra, Cytra-2, Liqui-Dual Citra, Oracit, Shohl's Solution, Virtrate-2
Synonyms: Citric acid and sodium citrate, Sodium Citrate and Citric Acid
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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- Sodium Citrate and Citric Acid Oral Solution-Methotrexate Injection (Subcutaneous)
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