Methotrexate injection and Theophylline and guaifenesin
Determining the interaction of Methotrexate injection and Theophylline and guaifenesin and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using theophylline together with methotrexate may increase the effects of theophylline. Contact your doctor if you experience nausea, vomiting, insomnia, tremors, restlessness, uneven heartbeats, and seizure (convulsions). If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Methotrexate may reduce oral theophylline clearance. Intramuscular methotrexate (15 mg/kg weekly) has been reported to lead to a 19% decrease in theophylline clearance. The mechanism has not been described. Patients who are maintained on theophylline may exhibit toxicity if methotrexate is added to the regimen.
MANAGEMENT: The clinician should observe closely for alterations in theophylline serum levels and signs of toxicity. Patients should be advised to report any signs of theophylline toxicity including nausea, vomiting, diarrhea, headache, restlessness, insomnia, or irregular heartbeat.
- Glynn-Barnhart A, Szefler S, Cott G "Effect of methotrexate on prednisolone and theophylline pharmacokinetics." Clin Pharmacol Ther 47 (1990): 130
Generic Name: methotrexate
Brand name: Otrexup, Rasuvo, Rheumatrex Dose Pack, Trexall, Xatmep, Methotrexate Sodium, Preservative Free
Synonyms: Methotrexate
Generic Name: guaifenesin / theophylline
Brand name:
Synonyms: Theophylline and guaifenesin (Oral)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Methotrexate injection-Theophylline Elixir
- Methotrexate injection-Theophylline in Dextrose
- Methotrexate injection-Theophylline Injection
- Methotrexate injection-Theophylline Intravenous
- Methotrexate injection-Theophylline Liquid
- Methotrexate injection-Theophylline Oral Solution
- Theophylline and guaifenesin-Methotrexate Injection (Subcutaneous)
- Theophylline and guaifenesin-Methotrexate Oral Solution
- Theophylline and guaifenesin-Methotrexate Oral, Injection
- Theophylline and guaifenesin-Methotrexate Sodium
- Theophylline and guaifenesin-Methotrexate Tablets
- Theophylline and guaifenesin-Methoxsalen