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Methotrexate Oral, Injection and Neoral

Determining the interaction of Methotrexate Oral, Injection and Neoral and the possibility of their joint administration.

Check result:

Methotrexate Oral, Injection <> Neoral

Relevance: 13.12.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using methotrexate together with cycloSPORINE can lead to increased side effects. Call the doctor if you experience nausea, vomiting, mouth sores, diarrhea, abdominal pain, dizziness, fatigue, or headache. If your doctor prescribes these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Concomitant administration of cyclosporine and methotrexate may be associated with an increased risk of toxicity. In rheumatoid arthritis patients (n=20), the concentrations of methotrexate were increased by 30% and concentrations of the 7-hydroxy metabolite decreased by 80%. There was no significant change in cyclosporine concentrations (n=6). The mechanism is unknown.

MANAGEMENT: Close monitoring of cyclosporine and methotrexate concentrations, renal function, and liver enzymes is recommended during concurrent therapy. Dosage adjustments may be necessary. Patients should be advised to report any nausea, vomiting, mouth sores, diarrhea, abdominal pain, dizziness, fatigue, or headache.

References

Powles AV, Baker BS, Fry L "Cyclosporin toxicity." Lancet 335 (1990): 610
Korstanje MJ, van Breda Vriesman CJ, van de Staak WJ "Cyclosporine and methotrexate: a dangerous combination." J Am Acad Dermatol 23 (1990): 320-1
Cockburn IT, Krupp P "An appraisal of drug interactions with sandimmun." Transplant Proc 21 (1989): 3845-50
"Product Information. Sandimmune (cyclosporine)." Sandoz Pharmaceuticals Corporation, East Hanover, NJ.

Methotrexate Oral, Injection

Generic Name: methotrexate

Brand name: Otrexup, Rasuvo, Rheumatrex Dose Pack, Trexall, Xatmep, Methotrexate Sodium, Preservative Free

Synonyms: Methotrexate

What is Methotrexate Oral, Injection?

Neoral

Generic Name: cyclosporine

Brand name: Gengraf, Neoral, Sandimmune, Sandimmune

Synonyms: Neoral (Capsules, Modified)

What is Neoral?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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