Methotrexate Oral, Injection and Prenaissance Next-B
Determining the interaction of Methotrexate Oral, Injection and Prenaissance Next-B and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Folic acid may reduce the effects of methotrexate. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration of methotrexate with vitamin preparations containing folic acid, folinic acid (leucovorin) or their derivatives may diminish the therapeutic effects of methotrexate. The proposed mechanism involves pharmacodynamic antagonism and/or competitive inhibition at the receptor site.
MANAGEMENT: Although folic acid or folinic acid are frequently used along with methotrexate to reduce adverse effects or as an antidote to high dose methotrexate therapy, patients receiving methotrexate should be advised to avoid the inadvertent use of vitamin preparations containing folic acid or its derivatives.
- "Product Information. Methotrexate Sodium (methotrexate)." Teva Pharmaceuticals (formerly IVAX), Miami, FL.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- Cerner Multum, Inc. "Australian Product Information." O 0
Generic Name: methotrexate
Brand name: Otrexup, Rasuvo, Rheumatrex Dose Pack, Trexall, Xatmep, Methotrexate Sodium, Preservative Free
Synonyms: Methotrexate
Generic Name: calcium / folic acid / ginger / pyridoxine
Brand name: Prenaissance Next, Prenaissance Next-B
Synonyms: Vitamin B6, Ginger, Folic Acid, and Calcium
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Methotrexate Oral, Injection-Prenaissance Plus
- Methotrexate Oral, Injection-PreNata
- Methotrexate Oral, Injection-PreNata Chewable Tablets
- Methotrexate Oral, Injection-Prenatabs FA
- Methotrexate Oral, Injection-Prenatabs FA Tablets
- Methotrexate Oral, Injection-Prenatabs Rx
- Prenaissance Next-B-Methotrexate Sodium
- Prenaissance Next-B-Methotrexate Tablets
- Prenaissance Next-B-Methoxsalen
- Prenaissance Next-B-Methoxsalen (Systemic)
- Prenaissance Next-B-Methoxsalen (Topical)
- Prenaissance Next-B-Methoxsalen Extracorporeal Solution