Methotrexate Oral Solution and Theophylline in Dextrose
Determining the interaction of Methotrexate Oral Solution and Theophylline in Dextrose and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using theophylline together with methotrexate may increase the effects of theophylline. Contact your doctor if you experience nausea, vomiting, insomnia, tremors, restlessness, uneven heartbeats, and seizure (convulsions). If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Methotrexate may reduce oral theophylline clearance. Intramuscular methotrexate (15 mg/kg weekly) has been reported to lead to a 19% decrease in theophylline clearance. The mechanism has not been described. Patients who are maintained on theophylline may exhibit toxicity if methotrexate is added to the regimen.
MANAGEMENT: The clinician should observe closely for alterations in theophylline serum levels and signs of toxicity. Patients should be advised to report any signs of theophylline toxicity including nausea, vomiting, diarrhea, headache, restlessness, insomnia, or irregular heartbeat.
- Glynn-Barnhart A, Szefler S, Cott G "Effect of methotrexate on prednisolone and theophylline pharmacokinetics." Clin Pharmacol Ther 47 (1990): 130
Generic Name: methotrexate
Brand name: Otrexup, Rasuvo, Rheumatrex Dose Pack, Trexall, Xatmep, Methotrexate Sodium, Preservative Free
Synonyms: Methotrexate
Generic Name: theophylline
Brand name: Elixophyllin, Theo-24, Respbid, T-Phyl, Aerolate III, Slo-Bid Gyrocaps, Slo-Phyllin, Theobid, Theo-Dur, Theolair, Theovent, Bronkodyl, Theo-X, Theo-Time, Theochron, Slo-Phyllin 125, Theoclear LA-130, Aerolate JR, Theolair-SR, Theoclear LA-260, Quibron-T, Quibron-T/SR, Uniphyl, Uni-Dur, Aerolate SR, Slo-Phyllin 80, Theoclear-80, Theo-Dur Sprinkles, Theosol-80, Asmalix, Aquaphyllin, Truxophyllin, Slo-Phyllin 250, TheoCap
Synonyms: Theophylline
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Methotrexate Oral Solution-Theophylline Injection
- Methotrexate Oral Solution-Theophylline Intravenous
- Methotrexate Oral Solution-Theophylline Liquid
- Methotrexate Oral Solution-Theophylline Oral Solution
- Methotrexate Oral Solution-Theophylline Sustained-Release Capsules
- Methotrexate Oral Solution-Theophylline Sustained-Release Tablets
- Theophylline in Dextrose-Methotrexate Oral, Injection
- Theophylline in Dextrose-Methotrexate Sodium
- Theophylline in Dextrose-Methotrexate Tablets
- Theophylline in Dextrose-Methoxsalen
- Theophylline in Dextrose-Methoxsalen (Systemic)
- Theophylline in Dextrose-Methoxsalen (Topical)