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Methotrexate Oral Solution and Truxophyllin

Determining the interaction of Methotrexate Oral Solution and Truxophyllin and the possibility of their joint administration.

Check result:

Methotrexate Oral Solution <> Truxophyllin

Relevance: 09.11.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using theophylline together with methotrexate may increase the effects of theophylline. Contact your doctor if you experience nausea, vomiting, insomnia, tremors, restlessness, uneven heartbeats, and seizure (convulsions). If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Methotrexate may reduce oral theophylline clearance. Intramuscular methotrexate (15 mg/kg weekly) has been reported to lead to a 19% decrease in theophylline clearance. The mechanism has not been described. Patients who are maintained on theophylline may exhibit toxicity if methotrexate is added to the regimen.

MANAGEMENT: The clinician should observe closely for alterations in theophylline serum levels and signs of toxicity. Patients should be advised to report any signs of theophylline toxicity including nausea, vomiting, diarrhea, headache, restlessness, insomnia, or irregular heartbeat.

References

Glynn-Barnhart A, Szefler S, Cott G "Effect of methotrexate on prednisolone and theophylline pharmacokinetics." Clin Pharmacol Ther 47 (1990): 130

Methotrexate Oral Solution

Generic Name: methotrexate

Brand name: Otrexup, Rasuvo, Rheumatrex Dose Pack, Trexall, Xatmep, Methotrexate Sodium, Preservative Free

Synonyms: Methotrexate

What is Methotrexate Oral Solution?

Truxophyllin

Generic Name: theophylline

Brand name: Elixophyllin, Theo-24, Respbid, T-Phyl, Aerolate III, Slo-Bid Gyrocaps, Slo-Phyllin, Theobid, Theo-Dur, Theolair, Theovent, Bronkodyl, Theo-X, Theo-Time, Theochron, Slo-Phyllin 125, Theoclear LA-130, Aerolate JR, Theolair-SR, Theoclear LA-260, Quibron-T, Quibron-T/SR, Uniphyl, Uni-Dur, Aerolate SR, Slo-Phyllin 80, Theoclear-80, Theo-Dur Sprinkles, Theosol-80, Asmalix, Aquaphyllin, Truxophyllin, Slo-Phyllin 250, TheoCap

Synonyms: Truxophyllin (Oral)

What is Truxophyllin?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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