Methoxsalen Hard-Gelatin Capsules and Spironolactone and hydrochlorothiazide
Determining the interaction of Methoxsalen Hard-Gelatin Capsules and Spironolactone and hydrochlorothiazide and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this interaction is not currently available.MONITOR: Concomitant use of methoxsalen with other known photosensitizing agents may increase the risk of photosensitivity reactions. These agents include anthralin, coal tar or coal tar derivatives, griseofulvin, hypericin extracts (e.g., St John's Wort), fluoroquinolones, phenothiazines, retinoids, halogenated salicylanilides (bacteriostatic soaps), sulfonamides, sulfonylureas, tetracyclines, thiazides, and certain organic staining dyes such as methylene blue, toluidine blue, rose bengal, and methyl orange. MANAGEMENT: Caution is advised and pharmacologic response to methoxsalen therapy should be carefully monitored if concomitant use of other photosensitizing agents cannot be avoided. Patients should be advised to avoid sun exposure, even through window glass or cloud cover, for at least 8 hours after methoxsalen ingestion and during the 24 hours following photochemotherapy or photopheresis treatment. Protective devices should be used if sun exposure cannot be avoided, such as a hat and gloves and/or sunscreens containing ingredients that filter out UVA radiation (e.g., benzophenone and/or PABA esters). Sunscreens must be applied to all areas that might be exposed to the sun, including the lips. For the treatment of psoriasis, sunscreens should not be applied to areas affected by psoriasis until after treatment in the UVA chamber. In addition, UVA-absorbing wrap-around sunglasses should be worn during daylight for 24 hours after methoxsalen ingestion and during the 24 hours following photochemotherapy or photopheresis treatment to prevent the irreversible binding of methoxsalen to proteins and DNA components of the lens, which can lead to formation of cataracts. The glasses should be worn any time patients are exposed to direct or indirect sunlight, whether they are outdoors or exposed through a window. Because erythema and/or burning due to photochemotherapy and sunburn due to sun exposure are additive, patients should not sunbathe for 48 hours after photochemotherapy. References "Product Information. Uvadex (methoxsalen)." Therakos Inc, Exton, PA. Cerner Multum, Inc. "Australian Product Information." O 0 "Multum Information Services, Inc. Expert Review Panel" "Product Information. Oxsoralen (methoxsalen)." ICN Pharmaceuticals Inc, Costa Mesa, CA. View all 4 references
Professional:MONITOR: Concomitant use of methoxsalen with other known photosensitizing agents may increase the risk of photosensitivity reactions. These agents include anthralin, coal tar or coal tar derivatives, griseofulvin, hypericin extracts (e.g., St John's Wort), fluoroquinolones, phenothiazines, retinoids, halogenated salicylanilides (bacteriostatic soaps), sulfonamides, sulfonylureas, tetracyclines, thiazides, and certain organic staining dyes such as methylene blue, toluidine blue, rose bengal, and methyl orange.
MANAGEMENT: Caution is advised and pharmacologic response to methoxsalen therapy should be carefully monitored if concomitant use of other photosensitizing agents cannot be avoided. Patients should be advised to avoid sun exposure, even through window glass or cloud cover, for at least 8 hours after methoxsalen ingestion and during the 24 hours following photochemotherapy or photopheresis treatment. Protective devices should be used if sun exposure cannot be avoided, such as a hat and gloves and/or sunscreens containing ingredients that filter out UVA radiation (e.g., benzophenone and/or PABA esters). Sunscreens must be applied to all areas that might be exposed to the sun, including the lips. For the treatment of psoriasis, sunscreens should not be applied to areas affected by psoriasis until after treatment in the UVA chamber. In addition, UVA-absorbing wrap-around sunglasses should be worn during daylight for 24 hours after methoxsalen ingestion and during the 24 hours following photochemotherapy or photopheresis treatment to prevent the irreversible binding of methoxsalen to proteins and DNA components of the lens, which can lead to formation of cataracts. The glasses should be worn any time patients are exposed to direct or indirect sunlight, whether they are outdoors or exposed through a window. Because erythema and/or burning due to photochemotherapy and sunburn due to sun exposure are additive, patients should not sunbathe for 48 hours after photochemotherapy.
- "Product Information. Uvadex (methoxsalen)." Therakos Inc, Exton, PA.
- Cerner Multum, Inc. "Australian Product Information." O 0
- "Multum Information Services, Inc. Expert Review Panel"
- "Product Information. Oxsoralen (methoxsalen)." ICN Pharmaceuticals Inc, Costa Mesa, CA.
Generic Name: methoxsalen
Brand name: 8-Mop, Oxsoralen-Ultra, Uvadex
Synonyms: Methoxsalen, Methoxsalen (Systemic)
Generic Name: hydrochlorothiazide / spironolactone
Brand name: Aldactazide
Synonyms: Hydrochlorothiazide and spironolactone, Hydrochlorothiazide and Spironolactone
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Methoxsalen Hard-Gelatin Capsules-Spironolactone Oral Suspension
- Methoxsalen Hard-Gelatin Capsules-Spironolactone Tablets
- Methoxsalen Hard-Gelatin Capsules-SpongeBob SquarePants Gummies
- Methoxsalen Hard-Gelatin Capsules-Sporanox
- Methoxsalen Hard-Gelatin Capsules-Sporanox (Itraconazole Capsules (Sporanox))
- Methoxsalen Hard-Gelatin Capsules-Sporanox (Itraconazole Oral Solution)
- Spironolactone and hydrochlorothiazide-Methoxsalen injection
- Spironolactone and hydrochlorothiazide-Methoxsalen Soft-Gelatin Capsules
- Spironolactone and hydrochlorothiazide-Methoxy Polyethylene Glycol-Epoetin Beta
- Spironolactone and hydrochlorothiazide-Methoxy polyethylene glycol-epoetin beta Injection
- Spironolactone and hydrochlorothiazide-Methoxyflurane
- Spironolactone and hydrochlorothiazide-Methscopolamine