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Methoxyflurane and Nitrous Oxide

Determining the interaction of Methoxyflurane and Nitrous Oxide and the possibility of their joint administration.

Check result:

Methoxyflurane <> Nitrous Oxide

Relevance: 12.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Coadministration of 70% nitrous oxide reduces the dosage requirements for halogenated inhalation anesthetics. Minimum alveolar concentration (MAC) values can be reduced from 0.75% to 0.29% for halothane, from 1.68% to 0.6% for enflurane, and from 1.15% to 0.5% for isoflurane. The MAC equivalent dose for sevoflurane is reduced by approximately 50% in the presence of 50% nitrous oxide.

References

Hardman JG, Gilman AG, Limbird LE eds. "Goodman and Gilman's the Pharmacological Basis of Therapeutics. 9th ed." New York, NY: McGraw-Hill (1995):
"Product Information. Ultane (sevoflurane)." Abbott Pharmaceutical, Abbott Park, IL.

Methoxyflurane

Generic Name: methoxyflurane

Brand name:

Synonyms: n.a.

What is Methoxyflurane?

Nitrous Oxide

Generic Name: nitrous oxide

Brand name:

Synonyms: n.a.

What is Nitrous Oxide?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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