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Methoxyflurane and Tetracap

Determining the interaction of Methoxyflurane and Tetracap and the possibility of their joint administration.

Check result:
Methoxyflurane <> Tetracap
Relevance: 12.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Ask your doctor before using tetracycline together with methoxyflurane. Both medications can be harmful to the kidneys, and these effects are increased when the medications are used together. Symptoms of kidney damage include swelling, weight gain, feeling short of breath, drowsiness, confusion, mood changes, increased thirst, loss of appetite, nausea and vomiting, pain in your lower back, and urinating more or less than usual or not at all. If you take both medications together, tell your doctor if you have any of these symptoms. You may need a dose adjustment or special tests to safely use these medications together. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Coadministration of tetracycline or oxytetracycline with methoxyflurane has enhanced renal toxicity. Fatalities have been reported. The mechanism is not known.

MANAGEMENT: This combination should be avoided if possible.

References
  • Kuzucu EY "Methoxyflurane, tetracycline, and renal failure." JAMA 211 (1970): 1162-4
  • Cousins MJ, Mazze RI "Methoxyfluranne nephrotoxicity. A study of dose response in man." JAMA 225 (1973): 1611-6
  • Albers DD, Leverett CL, Sandin JH "Renal failure following prostatovesiculectomy related to methoxyflurane anesthesia and tetracycline-complicated by candida infection." J Urol 106 (1971): 348-50
  • Proctor EA, Barton FL "Polyuric acute renal failure after methoxyflurane and tetracycline." Br Med J 4 (1971): 661-2
  • "Product Information. Declomycin (demeclocycline)." Lederle Laboratories, Wayne, NJ.
Methoxyflurane

Generic Name: methoxyflurane

Brand name:

Synonyms: n.a.

Tetracap

Generic Name: tetracycline

Brand name: Ala-Tet, Brodspec, Panmycin, Sumycin, Tetracap, Tetracon, Robitet 500, Emtet-500

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

Interaction with food and lifestyle
Disease interaction