Methscopolamine Bromide and Spironolactone and hydrochlorothiazide
Determining the interaction of Methscopolamine Bromide and Spironolactone and hydrochlorothiazide and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Anticholinergic agents may increase the absorption and oral bioavailability of thiazide diuretics. The proposed mechanism involves increased gastrointestinal transit time due to reduction of stomach and intestinal motility by anticholinergic agents. In six healthy volunteers, pretreatment with propantheline prolonged the time to reach peak plasma concentration (Tmax) for hydrochlorothiazide from 2.4 to 4.8 hours and increased its total 48-hour urinary recovery by 36%. Similar results were reported for chlorothiazide in another study. The clinical significance of these changes is unknown.
- Osman MA, Welling PG "Influence of propantheline and metoclopramide on the bioavailability of chlorothiazide." Curr Ther Res Clin Exp 34 (1983): 404-8
- Beermann B, Groschinsky-Grind M "Enhancement of the gastrointestinal absorption of hydrochlorothiazide by propantheline." Eur J Clin Pharmacol 13 (1978): 385-7
Generic Name: methscopolamine
Brand name: Pamine, Pamine Forte
Synonyms: Methscopolamine
Generic Name: hydrochlorothiazide / spironolactone
Brand name: Aldactazide
Synonyms: Hydrochlorothiazide and spironolactone, Hydrochlorothiazide and Spironolactone
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Methscopolamine Bromide-Spironolactone Oral Suspension
- Methscopolamine Bromide-Spironolactone Tablets
- Methscopolamine Bromide-SpongeBob SquarePants Gummies
- Methscopolamine Bromide-Sporanox
- Methscopolamine Bromide-Sporanox (Itraconazole Capsules (Sporanox))
- Methscopolamine Bromide-Sporanox (Itraconazole Oral Solution)
- Spironolactone and hydrochlorothiazide-Methsuximide
- Spironolactone and hydrochlorothiazide-Methyclothiazide
- Spironolactone and hydrochlorothiazide-Methyl Aminolevulinate
- Spironolactone and hydrochlorothiazide-Methyl aminolevulinate topical
- Spironolactone and hydrochlorothiazide-Methyl aminolevulinate Topical application
- Spironolactone and hydrochlorothiazide-Methyl B-12 vitamin B12