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Methyldopa and Hydrochlorothiazide and Nembutal

Determining the interaction of Methyldopa and Hydrochlorothiazide and Nembutal and the possibility of their joint administration.

Check result:

Methyldopa and Hydrochlorothiazide <> Nembutal

Relevance: 18.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Some barbiturates may increase the plasma clearance of methyldopa. Antihypertensive effectiveness may be decreased. Data are available for phenobarbital only and are conflicting. The clinical relevance of this interaction is minimal.

References

Kristensen M, Jorgensen M, Hansen T "Plasma concentration of alfamethyldopa and its main metabolite, methyldopa-O-sulphate during long-term treatment with alfamethyldopa with special reference to possible interaction with other drugs given simultaneously." Clin Pharmacol Ther 14 (1973): 139-40
Kaldor A, Juvancz P, Demeczky M, et al "Enhancement of methyldopa metabolism with barbiturate." Br Med J 3 (1971): 518-9
Kristensen M, Jorgensen M, Hansen T "Barbiturates and methyldopa metabolism." Br Med J 1 (1973): 49

Methyldopa and Hydrochlorothiazide

Generic Name: hydrochlorothiazide / methyldopa

Brand name: Aldoril 15, Aldoril 25, Aldoril D30, Aldoril D50

Synonyms: Hydrochlorothiazide and methyldopa

What is Methyldopa and Hydrochlorothiazide?

Nembutal

Generic Name: pentobarbital

Brand name: Nembutal, Nembutal Sodium

Synonyms: n.a.

What is Nembutal?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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