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Methyldopa and Hydrochlorothiazide and Timoptic-XE

Determining the interaction of Methyldopa and Hydrochlorothiazide and Timoptic-XE and the possibility of their joint administration.

Check result:

Methyldopa and Hydrochlorothiazide <> Timoptic-XE

Relevance: 18.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Ask your doctor before using timolol ophthalmic together with methyldopa. This can cause lead to a serious increase in your blood pressure. Call your doctor if you experience nausea, vomiting, sweating, flushing, stiff neck, headache, or heart palpitations. If you take both medications together, tell your doctor if you have any of these symptoms. You may need a dose adjustment or need your blood pressure checked more often if you take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: The combination of nonselective beta-blockers and methyldopa may cause hypertensive crises. Death has been reported. Causality has not been clearly established, as other drugs were involved. The mechanism may be related to unopposed alpha effects. Phentolamine may be useful for treatment of this interaction.

MANAGEMENT: It may be best to avoid this combination. Patients' blood pressure should be monitored during concurrent therapy. Patients should be advised to seek medical help if they experience any early symptoms of a hypertensive crisis including nausea, vomiting, sweating, flushing, stiff neck, headache, or palpitations.

References

McLaren EH "Severe hypertension produced by interaction of phenylpropanolamine with methyldopa and oxprenolol." Br Med J 2 (1976): 283-4
Nies AS, Shand DG "Hypertensive response to propranolol in a patient treated with methyldopa: a proposed mechanism." Clin Pharmacol Ther 14 (1973): 823-6

Methyldopa and Hydrochlorothiazide

Generic Name: hydrochlorothiazide / methyldopa

Brand name: Aldoril 15, Aldoril 25, Aldoril D30, Aldoril D50

Synonyms: Hydrochlorothiazide and methyldopa

What is Methyldopa and Hydrochlorothiazide?

Timoptic-XE

Generic Name: timolol ophthalmic

Brand name: Betimol, Istalol, Timoptic Ocudose, Timoptic Ocumeter, Timoptic Ocumeter Plus, Timoptic-XE, Timoptic

Synonyms: Timoptic XE

What is Timoptic-XE?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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