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Methyldopa Oral, Intravenous and Tolazamide

Determining the interaction of Methyldopa Oral, Intravenous and Tolazamide and the possibility of their joint administration.

Check result:
Methyldopa Oral, Intravenous <> Tolazamide
Relevance: 06.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Methyldopa may inhibit the metabolism of some antidiabetic agents. The serum half-life and the effectiveness of those agents may be increased, and unexpected hypoglycemia could result. When methyldopa is added to or deleted from a medical regimen that includes antidiabetic agents, the patient should be made aware of this interaction. Blood glucose should be checked more frequently, if necessary.

References
  • Gachalyi B, Tornyossy, Vas A, Kaldor A "Effect of alphamethyldopa on the half-lives of antipyrine, tolbutamide and D-glucaric acid excretion in man." Int J Clin Pharmacol Ther Toxicol 18 (1980): 133-5
Methyldopa Oral, Intravenous

Generic Name: methyldopa

Brand name: Aldomet

Synonyms: Methyldopa

Tolazamide

Generic Name: tolazamide

Brand name: Tolinase

Synonyms: TOLAZamide

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

Interaction with food and lifestyle