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Methyldopa Tablets and Zyvox (Linezolid Suspension)

Determining the interaction of Methyldopa Tablets and Zyvox (Linezolid Suspension) and the possibility of their joint administration.

Check result:

Methyldopa Tablets <> Zyvox (Linezolid Suspension)

Relevance: 18.01.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using methyldopa together with linezolid is not recommended. Combining these medications may increase your blood pressure or cause central nervous system stimulation that can result in agitation and hallucinations. You may use methyldopa only after you have been off linezolid for at least 14 days. You should seek immediate medical attention if you experience sudden and severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, lightheadedness, and/or fainting during treatment with linezolid, as these may be signs and symptoms of excessively high blood pressure. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

CONTRAINDICATED: Coadministration of methyldopa and monoamine oxidase inhibitors (MAOIs) may result in loss of blood pressure control and/or signs of central stimulation such as hyperexcitability and hallucinations. The mechanism may involve excessive sympathetic stimulation in the central nervous system.

MANAGEMENT: Concurrent use of methyldopa with MAOIs or other agents that possess MAOI activity (e.g., furazolidone, linezolid, methylene blue, procarbazine) is considered contraindicated. At least 14 days should elapse between discontinuation of MAOI therapy and initiation of treatment with methyldopa.

References

van Rossum JM "Potential danger of monoamineoxidase inhibitors and a-methyldopa." Lancet 1 (1963): 950-1
van Rossum JM, Hurkmans JA "Reversal of the effect of a-Methyldopa by monamine oxidase inhibitors." J Pharm Pharmacol 15 (1963): 493-9
De Vita VT, Hahn MA, Oliverio VT "Monoamine oxidase inhibition by a new carcinostatic agent, n-isopropyl-a-(2-methylhydrazino)-p-toluamide (MIH). (30590)." Proc Soc Exp Biol Med 120 (1965): 561-5
"Product Information. Aldomet (methyldopa)." Merck & Co, Inc, West Point, PA.
Pettinger WA, Soyangco FG, Oates JA "Inhibition of monoamine oxidase in man by furazolidone." Clin Pharmacol Ther 9 (1968): 442-7
Schulz R, Antonin KH, Hoffmann E, et al "Tyramine kinetics and pressor sensitivity during monoamine oxidase inhibition by selegiline." Clin Pharmacol Ther 46 (1989): 528-36
Paykel ES "Hallucinosis on combined methyldopa and pargyline." Br Med J 1 (1966): 803
Darcy PF, Griffin JP "Interactions with drugs used in the treatment of depressive illness." Adverse Drug React Toxicol Rev 14 (1995): 211-31

Methyldopa Tablets

Generic Name: methyldopa

Brand name: Aldomet

Synonyms: Methyldopa

What is Methyldopa Tablets?

Zyvox (Linezolid Suspension)

Generic Name: linezolid

Brand name: Zyvox

Synonyms: Zyvox

What is Zyvox (Linezolid Suspension)?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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