Metoprolol and Hydrochlorothiazide Extended-Release Tablets and PEG-3350 with Electolytes
Determining the interaction of Metoprolol and Hydrochlorothiazide Extended-Release Tablets and PEG-3350 with Electolytes and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using metoprolol and hydroCHLOROthiazide together may lower your blood pressure and slow your heart rate. This can cause dizziness, or feeling like you might pass out, weakness, fainting, fast or irregular heartbeats, or loss of blood glucose control. If you take both medications together, tell your doctor if you have any of these symptoms. You may need a dose adjustment or need your blood pressure checked more often to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Although they are often combined in clinical practice, diuretics and beta-blockers may increase the risk of hyperglycemia and hypertriglyceridemia in some patients, especially in patients with diabetes or latent diabetes. In addition, the risk of QT interval prolongation and arrhythmias (e.g. torsades de pointes) due to sotalol may be increased by potassium-depleting diuretics.
MANAGEMENT: Monitoring of serum potassium levels, blood pressure, and blood glucose is recommended during coadministration. Patients should be advised to seek medical assistance if they experience dizziness, weakness, fainting, fast or irregular heartbeats, or loss of blood glucose control.
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- Dornhorst A, Powell SH, Pensky J "Aggravation by propranolol of hyperglycaemic effect of hydrochlorothiazide in type II diabetics without alteration of insulin secretion." Lancet 1 (1985): 123-6
- "Product Information. Lozol (indapamide)." Rhone-Poulenc Rorer, Collegeville, PA.
- Marcy TR, Ripley TL "Aldosterone antagonists in the treatment of heart failure." Am J Health Syst Pharm 63 (2006): 49-58
- Roux A, Le Liboux A, Delhotal B, Gaillot J, Flouvat B "Pharmacokinetics in man of acebutolol and hydrochlorothiazide as single agents and in combination." Eur J Clin Pharmacol 24 (1983): 801-6
Generic Name: hydrochlorothiazide / metoprolol
Brand name: Dutoprol, Lopressor HCT
Synonyms: Hydrochlorothiazide and metoprolol, Metoprolol and Hydrochlorothiazide
Generic Name: polyethylene glycol 3350 with electrolytes
Brand name: Colyte with Flavor Packs, GaviLyte-C, GoLYTELY, MoviPrep, NuLYTELY Orange, NuLYTELY with Flavor Packs, PEG-3350 with Electolytes, Plenvu, TriLyte with Flavor Packs, NuLYTELY, TriLyte, Suclear
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Metoprolol and Hydrochlorothiazide Extended-Release Tablets-PEG-3350, Sodium Chloride, Sodium Bicarbonate and Potassium Chloride
- Metoprolol and Hydrochlorothiazide Extended-Release Tablets-PEG-Prep and Bisacodyl
- Metoprolol and Hydrochlorothiazide Extended-Release Tablets-PEG3350
- Metoprolol and Hydrochlorothiazide Extended-Release Tablets-Pegademase bovine
- Metoprolol and Hydrochlorothiazide Extended-Release Tablets-Pegademase Bovine Injection
- Metoprolol and Hydrochlorothiazide Extended-Release Tablets-Pegademase bovine Intramuscular
- PEG-3350 with Electolytes-Metoprolol and Hydrochlorothiazide Tablets
- PEG-3350 with Electolytes-Metoprolol Extended-Release Capsules
- PEG-3350 with Electolytes-Metoprolol Extended-Release Tablets
- PEG-3350 with Electolytes-Metoprolol Injection
- PEG-3350 with Electolytes-Metoprolol Intravenous
- PEG-3350 with Electolytes-Metoprolol Succinate