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Metoprolol Extended-Release Capsules and Quin-G

Determining the interaction of Metoprolol Extended-Release Capsules and Quin-G and the possibility of their joint administration.

Check result:

Metoprolol Extended-Release Capsules <> Quin-G

Relevance: 26.11.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using quiNIDine and metoprolol together can lower your blood pressure and slow your heart rate. This can cause a slow heartbeat, headaches, dizziness, or feeling like you might pass out. If you take both medications together, tell your doctor if you have any of these symptoms. You may need a dose adjustment or need your blood pressure checked more often if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Quinidine may increase serum levels of some oral beta-blockers. The proposed mechanism is inhibition of CYP450 2D6 first-pass metabolism and decreased hepatic clearance of hepatically metabolized beta-blockers. Quinidine and beta-blockers may also have additive negative inotropic effects, which can be beneficial when used to treat atrial fibrillation. However, adverse effects have been reported with quinidine and propranolol.

MANAGEMENT: Patients should be monitored for orthostatic hypotension, cardiac arrhythmias, bradycardia, and heart failure, and beta-blocker dosage should be decreased if necessary.

References

Edeki TI, He H, Wood AJ "Pharmacogenetic explanation for excessive B-blockade following timolol eye drops." JAMA 274 (1995): 1611-3
Dorian P, Newman D, Berman N, Hardy J, Mitchell J "Sotalol and type IA drugs in combination prevent recurrence of sustained ventricular tachycardia." J Am Coll Cardiol 22 (1993): 106-13
Loon NR, Wilcox CS, Folger W "Orthostatic hypotension due to quinidine and propranolol." Am J Med 81 (1986): 1101-4
Zhou HH, Anthony LB, Roden DM, Wood AJ "Quinidine reduces clearance of (+)-propranolol more than (-)-propranolol through marked reduction in 4-hydroxylation." Clin Pharmacol Ther 47 (1990): 686-93
Kessler KM, Humphries WC, Black M, Spann JF "Quinidine pharmacokinetics in patients with cirrhosis or receiving propranolol." Am Heart J 96 (1978): 627-35
Manolis AS, Estes NA "Orthostatic hypotension due to quinidine and atenolol." Am J Med 82 (1987): 1083-4
Ochs HR, Greenblatt DJ, Woo E, et al "Effect of propranolol on pharmacokinetics and acute electrocardiographic changes following intravenous quinidine in humans." Pharmacology 17 (1978): 301-6
Dinai Y, Sharir M, Floman NN, Halkin H "Bradycardia induced by interaction between quinidine and ophthalmic timolol." Ann Intern Med 103 (1985): 890-1
Fenster P, Perrier D, Mayersohn M, Marcus FI "Kinetic evaluation of the propranolol-quinidine combination." Clin Pharmacol Ther 27 (1980): 450-3
Zhou HH, Wood AJ "Differences in stereoselective disposition of propranolol do not explain sensitivity differences between white and Chinese subjects: correlation between the clearance of (-)- and (+)- propranolol." Clin Pharmacol Ther 47 (1990): 719-23
Leemann T, Dayer P, Meyer UA "Single-dose quinidine treatment inhibits metoprolol oxidation in extensive metabolizers." Eur J Clin Pharmacol 29 (1986): 739-41

Metoprolol Extended-Release Capsules

Generic Name: metoprolol

Brand name: Kapspargo Sprinkle, Lopressor, Toprol-XL, Toprol XL

Synonyms: Metoprolol

What is Metoprolol Extended-Release Capsules?

Quin-G

Generic Name: quinidine

Brand name: Quin-G, Cardioquin, Quinora, Quinidex Extentabs, Quinaglute Dura-Tabs, Quin-Release

Synonyms: n.a.

What is Quin-G?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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