Metoprolol Extended-Release Capsules and Sulfinpyrazone
Determining the interaction of Metoprolol Extended-Release Capsules and Sulfinpyrazone and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Sulfinpyrazone may reduce the antihypertensive effect of beta-blockers. The mechanism may be related to induction of beta-blocker metabolism or inhibition of prostaglandin synthesis by sulfinpyrazone. Data are available for oxprenolol only. Close observation for altered beta-blocker effects is recommended if coadministration is necessary.
- Ferrara LA, Mancini M, Marotta T, Pasanisi F, Fasano ML "Interference by sulphinpyrazone with the antihypertensive effects of oxprenolol." Eur J Clin Pharmacol 29 (1986): 717-9
Generic Name: metoprolol
Brand name: Kapspargo Sprinkle, Lopressor, Toprol-XL, Toprol XL
Synonyms: Metoprolol
Generic Name: sulfinpyrazone
Brand name:
Synonyms: Sulfinpyrazone (Oral)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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