Metoprolol Extended-Release Capsules and Zileuton Tablets
Determining the interaction of Metoprolol Extended-Release Capsules and Zileuton Tablets and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using zileuton together with metoprolol may increase the effects of zileuton. Contact your doctor if you experience uneven heartbeats, shortness of breath, bluish-colored fingernails, dizziness, weakness, fainting, or seizure (convulsions). If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Zileuton is believed to inhibit the hepatic metabolism of propranolol. Propranolol serum concentrations may increase by as much as 100% with a resultant increase in beta blockade.
MANAGEMENT: It is unknown if this interaction will occur with other beta-blockers; however, if zileuton and a beta-blocker must be given concomitantly, the patient should be monitored for orthostatic hypotension, cardiac arrhythmias, bradycardia, and heart failure, and beta-blocker dosage should be decreased if necessary.
- "Product Information. Zylo Filmtab (zileuton)." Abbott Pharmaceutical, Abbott Park, IL.
Generic Name: metoprolol
Brand name: Kapspargo Sprinkle, Lopressor, Toprol-XL, Toprol XL
Synonyms: Metoprolol
Generic Name: zileuton
Brand name: Zyflo, Zyflo CR
Synonyms: Zileuton
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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