Metoprolol Injection and Septocaine with Epinephrine 1:200,000
Determining the interaction of Metoprolol Injection and Septocaine with Epinephrine 1:200,000 and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Beta-blockers like metoprolol may reduce the effects of vasopressors like EPINEPHrine. If you have been using metoprolol, you may not respond as well to vasopressors given to treat an emergency such as shock or a severe allergic reaction. Your healthcare provider should always be told if you are receiving, or have recently received, beta-blocker therapy. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Beta-blockers may antagonize the cardiostimulatory effects of pressor agents by blocking beta-1 adrenergic receptors in the heart. Vasopressors may be less effective if the patient is receiving, or has recently received, a beta-blocking drug. In addition, peripheral vascular resistance may increase due to unopposed alpha-adrenergic effects of pressor agents in the presence of beta-blockade. Theoretically, the interaction may also occur with beta-blocker ophthalmic preparations, since they may be systemically absorbed and can produce clinically significant systemic effects even at low or undetectable plasma levels.
MANAGEMENT: No specific intervention is necessary, but clinicians should be alert to the potential for diminished cardiac response when pressor agents are used in patients treated with beta-blockers, including ophthalmic formulations. A beta-blocker such as propranolol may be used to treat cardiac arrhythmias that occur during administration of pressor agents like mephentermine, metaraminol, norepinephrine, or phenylephrine.
- "Product Information. Dobutrex (dobutamine)." Lilly, Eli and Company, Indianapolis, IN.
- Richards DA, Prichard BN, Hernandez R "Circulatory effects of noradrenaline and adrenaline before and after labetalol." Br J Clin Pharmacol 7 (1979): 371-8
- "Product Information. Intropin (dopamine)." DuPont Pharmaceuticals, Wilmington, DE.
Generic Name: metoprolol
Brand name: Kapspargo Sprinkle, Lopressor, Toprol-XL, Toprol XL
Synonyms: Metoprolol
Generic Name: articaine / epinephrine
Brand name: Septocaine, Articadent, Orabloc, Septocaine with Epinephrine 1: 100, 000, Septocaine with Epinephrine 1: 200, Zorcaine
Synonyms: Articaine and epinephrine, Articaine and Epinephrine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Metoprolol Injection-Septra
- Metoprolol Injection-Septra DS
- Metoprolol Injection-Septra Pediatric Suspension
- Metoprolol Injection-Ser-Ap-Es
- Metoprolol Injection-Serax
- Metoprolol Injection-Serentil
- Septocaine with Epinephrine 1:200,000-Metoprolol Intravenous
- Septocaine with Epinephrine 1:200,000-Metoprolol Succinate
- Septocaine with Epinephrine 1:200,000-Metoprolol Succinate ER Capsules
- Septocaine with Epinephrine 1:200,000-Metoprolol Succinate ER Tablets
- Septocaine with Epinephrine 1:200,000-Metoprolol Tablets
- Septocaine with Epinephrine 1:200,000-Metoprolol Tartrate