Metoprolol Succinate and Zovia 1/35

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Ethinyl estradiol may increase the blood levels of metoprolol in some patients. This can cause greater decreases in blood pressure and heart rate. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Oral contraceptives containing ethinyl estradiol may interfere with the first-pass metabolism of certain beta-blockers and increase their plasma concentrations. In one study, young, healthy female subjects receiving a low-dose ethinyl estradiol oral contraceptive (OC) demonstrated higher plasma levels of metoprolol (100 mg), oxprenolol (80 mg), and propranolol (80 mg) following single-dose administration than control subjects who were not receiving an OC. Specifically, mean metoprolol peak plasma concentration (Cmax) and systemic exposure (AUC) were 36% and 71% higher, respectively, in OC users (n=12) than in non-users(n=11); mean oxprenolol Cmax and AUC were 6% and 26% higher, respectively, in OC users (n=7) than in non-users (n=8); and mean propranolol Cmax and AUC were 19% and 42% higher, respectively, in OC users (n=7) than in non-users (n=8). Only the difference in metoprolol AUC reached statistical significance, although the difference in propranolol AUC failed to reach significance by only a narrow margin.

MANAGEMENT: Pharmacologic effects including blood pressure and heart rate changes should be monitored more closely when metoprolol, oxprenolol, and propranolol are coadministered with ethinyl estradiol oral contraceptives, and dosage adjustments made as necessary.

Metoprolol Succinate

Generic Name: metoprolol

Brand name: Kapspargo Sprinkle, Lopressor, Toprol-XL, Toprol XL

Synonyms: Metoprolol

What is Metoprolol Succinate?

Zovia 1/35

Generic Name: ethinyl estradiol / ethynodiol

Brand name: Kelnor, Zovia 1/35, Zovia 1/50, Demulen 1/35, Demulen 1/50, Zovia 1/35e, Kelnor 1/50, Kelnor 1/35, Zovia 1/50e

Synonyms: Zovia 1/35E

What is Zovia 1/35?