Metreleptin and Rocuronium Bromide

• Generic Name: metreleptin
• Dosage Forms: n.a.
• Other Brand Names: Myalept

• It is used to treat problems caused by not having enough of a certain hormone (leptin) in the body. It is only for use in people with congenital or acquired generalized lipodystrophy.

• Generic Name: rocuronium
• Dosage Forms: n.a.
• Other Brand Names: Zemuron

Production of skeletal muscle relaxation during surgery after general anesthesia has been induced.

Facilitation of endotracheal intubation (rapid sequence and routine tracheal intubation).

Also has been used to facilitate mechanical ventilation in the ICU; however, manufacturer states that prolonged use in this setting has not been evaluated. Whenever neuromuscular blocking agents are used in the ICU, consider benefits versus risks of such therapy and assess patients frequently to determine need for continued paralysis. (See Intensive Care Setting under Cautions.)

Compared with other neuromuscular blocking agents, rocuronium has a rapid onset and intermediate duration of action. Recommended as an alternative to succinylcholine for rapid sequence intubation. When given in sufficient doses (e.g., ≥1 mg/kg), produces similar intubating conditions to succinylcholine.