Metreleptin and Tri-Norinyl
Determining the interaction of Metreleptin and Tri-Norinyl and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Treatment with metreleptin may alter the blood levels and effects of ethinyl estradiol. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. You may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Treatment with metreleptin, a recombinant analog of human leptin, may affect the pharmacokinetics of drugs that are primarily metabolized by CYP450 isoenzymes. In leptin-deficient obese mice, administration of leptin has been shown to alter the hepatic levels of some CYP450 isoenzymes.
MANAGEMENT: Caution is advised when metreleptin is prescribed to patients receiving drugs with a narrow therapeutic index that are substrates of CYP450 isoenzymes, such as macrolide immunosuppressants, oral contraceptives, cyclosporine, theophylline, and warfarin. Clinical and laboratory monitoring are recommended following the initiation, discontinuation or change of dosage of metreleptin, and the individual dosage of the concomitant agents adjusted as needed.
- "Product Information. Myalept (metreleptin)." Bristol-Myers Squibb, Princeton, NJ.
Generic Name: ethinyl estradiol / norethindrone
Brand name: Blisovi 24 Fe, Estrostep Fe, Femcon Fe, Kaitlib FE, Lo Minastrin Fe, Microgestin 24 Fe, Norinyl 1+35, Ortho-Novum 7/7/7, Taytulla, Tri-Norinyl, Zenchent, Blisovi 24 Fe, Blisovi Fe 15/30, Blisovi Fe 1/20, Gildess 24 Fe, Gildess Fe 15/30, Gildess Fe 1/20, Junel Fe 15/30, Junel Fe 1/20, Junel Fe 24, Larin 24 Fe, Larin Fe 15/30, Larin Fe 1/20, Lo Loestrin Fe, Loestrin 24 Fe, Loestrin Fe 15/30, Loestrin Fe 1/20, Lomedia 24 Fe, Microgestin 24 Fe, Microgestin Fe 15/30, Microgestin Fe 1/20, Tarina Fe 1/20, Tilia Fe, Tri-Legest Fe, femhrt 05 mg/25 mcg, Fyavolv, Jevantique Lo, Jinteli, Femcon Fe, Generess FE, Loestrin 1/20, Ovcon 35, Brevicon
Synonyms: Tri-Norinyl (birth control)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Metreleptin-Tri-Norinyl birth control
- Metreleptin-Tri-Previfem
- Metreleptin-Tri-Sprintec
- Metreleptin-Tri-Vi-Flor
- Metreleptin-Tri-Vi-Floro
- Metreleptin-Tri-Vi-Sol
- Tri-Norinyl-Metreleptin Subcutaneous
- Tri-Norinyl-MetroCream
- Tri-Norinyl-Metrocream Topical
- Tri-Norinyl-MetroGel
- Tri-Norinyl-MetroGel (Metronidazole Cream, Gel, and Lotion)
- Tri-Norinyl-MetroGel (Metronidazole Gel and Cleansing Lotion)